Triamcinolone
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| Systematic (IUPAC) name | |
| (11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione | |
| Clinical data | |
| Trade names | Kenalog |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | A (AU) C (US) |
| Legal status | POM (UK) ℞-only (US) |
| Routes | Oral, topical, IM, intra-articular, intrasynovial |
| Pharmacokinetic data | |
| Protein binding | 68% |
| Metabolism | Hepatic |
| Half-life | 88 minutes |
| Excretion | Fecal and renal |
| Identifiers | |
| CAS number | 124-94-7 |
| ATC code | A01AC01 C05AA12, D07AB09, H02AB08, R01AD11, R03BA06, S01BA05 |
| PubChem | CID 31307 |
| DrugBank | APRD00422 |
| ChemSpider | 29046  |
| UNII | 1ZK20VI6TY |
| KEGG | D00385 |
| ChEMBL | CHEMBL1451 |
| Synonyms |
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(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one |
| Chemical data | |
| Formula | C21H27FO6 |
| Mol. mass | 394.434 g/mol |
| SMILES | eMolecules & PubChem |
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Triamcinolone (trade names Aristocort, Kenacort, Tri-Nasal, Triaderm, Azmacort, Trilone, Volon A, Tristoject, and Tricortone) is a long-acting synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.
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[edit] Uses
Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammation, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.[1][2][3]
Prior to 2007 it was manufactured under the name Azmacort as a corticosteroid inhaler for asthma long-term care. The patent holder, Sanofi, sold it under the brand name Nasacort.
In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.[4]
Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.
Triamcinolone acetonide is one of the ingredients of Ledermix - an endodontic (tooth's root canal) lotion used between sessions.
[edit] Forms
Different triamcinolone salts are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.
Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.
[edit] Side effects
Side effects of Triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.[5] An additional side effect for women is a prolonged menstrual cycle.
[edit] References
- ^ Triamcinolone - Drugs.com
- ^ Triamcinolone Inhalation - Drugs.com
- ^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
- ^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
- ^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. http://www.webmd.com/drugs/drug-16244-Nasacort+AQ.aspx?drugid=16244&drugname=Nasacort%20AQ. Retrieved 2008-03-24.
[edit] External links
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