As early as 1930, the road was named Wall Street in the city limits of Fayetteville. The road later became 6th Street. Between 1971 and 1989 this road was designated US 62 Business.
On January 15, 2009, Fayetteville renamed Sixth Street to Martin Luther King Jr. Boulevard. The ceremony took place at the Razorback Road intersection at the entrance to the University of Arkansas. Most Fayetteville businesses on the road still claim 6th Street, and many residents and university students continue to call the road 6th Street over two years after the change.
Arkansas Highway 180 was a state highway of 1.5 miles (2.4 km) in Fayetteville. Its original location was along Assembly Road and Skyline Drive where it circled around Mount Sequoyah and returned to its single terminus of Highway 45. This segment was dropped from the state highway system in the early 1990s.
Arkansas Highway 180 was a state highway of 1.8 miles (2.9 km) in Fayetteville. The route began at U.S. Route 71 Business in Fayetteville and followed Township Road, Gregg Ave and Drake Street before ending at AR 112. In the 1990s this segment was extended north along Gregg Ave and ended at a spur of U.S. 71 Business on the north end of Fayetteville. This segment was dropped from the state highway system in 2008 following the widening of Gregg Ave.