Arkansas Highway 399 is a short north–south highway in southwestern Arkansas. Its southern terminus is at an intersection with U.S. Route 70 Business in DeQueen. Its northern terminus is at U.S. Route 70 west of DeQueen.
There was once a second roadway with the Highway 399 designation, located west of Foreman in Little River County. It was the old location of Highway 32 through Arkinda to the Oklahoma border. This road is now County Road 63.