Armadillo repeats
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| Structure of the armadillo repeat region of beta-catenin.[1] | |||||||||
| Identifiers | |||||||||
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| Symbol | Arm | ||||||||
| Pfam | PF00514 | ||||||||
| Pfam clan | CL0020 | ||||||||
| InterPro | IPR000225 | ||||||||
| SMART | SM00185 | ||||||||
| PROSITE | PS50176 | ||||||||
| SCOP | 3bct | ||||||||
| SUPERFAMILY | 3bct | ||||||||
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Armadillo repeats are named after the β-catenin-like Armadillo protein of the fruit fly Drosophila.[2] These repeats are about 40 amino acids long and proteins that contain them have many tandemly repeated copies.[3][4] Each Armadillo repeat is composed of a pair of alpha helices that form a hairpin structure. Multiple copies of the repeat form what is known as an alpha solenoid structure. β-catenin is a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton[1], but the Armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important in transducing WNT signals during embryonic development.
[edit] References
- ^ a b Huber AH, Nelson WJ, Weis WI (September 1997). "Three-dimensional structure of the armadillo repeat region of beta-catenin". Cell 90 (5): 871–82. doi:10.1016/S0092-8674(00)80352-9. PMID 9298899.
- ^ Hatzfeld, M. (1999). "The armadillo family of structural proteins". International review of cytology. International Review of Cytology 186: 179–224. doi:10.1016/S0074-7696(08)61054-2. ISBN 9780123645906. PMID 9770300.
- ^ Peifer, M; Berg, S; Reynolds, AB (1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell 76 (5): 789–91. doi:10.1016/0092-8674(94)90353-0. PMID 7907279.
- ^ Groves, MR; Barford, D (1999). "Topological characteristics of helical repeat proteins". Current opinion in structural biology 9 (3): 383–9. doi:10.1016/S0959-440X(99)80052-9. PMID 10361086.
[edit] External links
- Eukaryotic Linear Motif resource motif class TRG_NLS_Bipartite_1
- Eukaryotic Linear Motif resource motif class TRG_NLS_MonoCore_2
- Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtC_3
- Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtN_4
- MeSH Armadillo+Domain+Proteins
- Armadillo/plakoglobin ARM repeat in PROSITE
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