Artemin

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Artemin
Artemin Tertiary Structure.png
Structure of human artemin.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARTN ; ENOVIN; EVN; NBN
External IDs OMIM603886 MGI1333791 HomoloGene7631 GeneCards: ARTN Gene
Orthologs
Species Human Mouse
Entrez 9048 11876
Ensembl ENSG00000117407 ENSMUSG00000028539
UniProt Q5T4W7 Q9Z0L2
RefSeq (mRNA) NM_001136215 NM_009711
RefSeq (protein) NP_001129687 NP_033841
Location (UCSC) Chr 1:
44.4 – 44.4 Mb
Chr 4:
117.93 – 117.93 Mb
PubMed search [1] [2]

Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.[2][3]

Function[edit]

Artemin is a neurotrophin in the glial cell line-derived neurotophic factor (GDNF ) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor.[2]

References[edit]

  1. ^ PDB 2GYR;Wang X, Baloh, RH, Milbrandt J, Garcia KC (June 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure 14 (6): 1083–1092. doi:10.1016/j.str.2006.05.010. PMID 16765900. ; rendered using PyMOL
  2. ^ a b "Entrez Gene: artemin". 
  3. ^ Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (December 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.