Asparagine synthetase

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asparagine synthetase
Identifiers
Symbol	ASNS
Entrez	440
HUGO	753
OMIM	108370
RefSeq	NM_001673
UniProt	P08243
Other data
EC number	6.3.5.4
Locus	Chr. 7 q21-q31

Asparagine synthetase (or aspartate-ammonia ligase) is an enzyme that generates asparagine from aspartate. This amidation reaction is similar to that promoted by glutamine synthetase.

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• MeSH Asparagine+synthetase

This ligase article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Enzymes: ligases (EC 6) 6.1: Carbon-Oxygen Aminoacyl tRNA synthetase (tyrosine-tRNA ligase, tryptophan-tRNA ligase, threonine-tRNA ligase, leucine-tRNA ligase, isoleucine-tRNA ligase, lysine-tRNA ligase, alanine-tRNA ligase, valine-tRNA ligase, methionine-tRNA ligase, serine-tRNA ligase, aspartate-tRNA ligase, D-alanine-poly(phosphoribitol) ligase, glycine-tRNA ligase, proline-tRNA ligase, cysteine-tRNA ligase, glutamate-tRNA ligase, glutamine-tRNA ligase, arginine-tRNA ligase, phenylalanine-tRNA ligase, histidine-tRNA ligase, asparagine-tRNA ligase, aspartate-tRNAAsn ligase, glutamate-tRNAGln ligase, lysine-tRNAPyl ligase) 6.2: Carbon-Sulfur Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase 6.3: Carbon-Nitrogen Glutamine synthetase - Ubiquitin ligase (Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthetase (I, II) - Gamma-glutamylcysteine synthetase 6.4: Carbon-Carbon Carbon-carbon ligases 6.5: Phosphoric Ester DNA ligase 6.6: Nitrogen-Metal Magnesium chelatase - Cobaltochelatase

v • d • e Metabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS) K→acetyl-CoA LYSINE→ Saccharopine dehydrogenase · Glutaryl-CoA dehydrogenase LEUCINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · Isovaleryl coenzyme A dehydrogenase · Methylcrotonyl-CoA carboxylase · Methylglutaconyl-CoA hydratase · 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase · Arylformamidase · Kynureninase · 3-hydroxyanthranilate oxidase · Aminocarboxymuconate-semialdehyde decarboxylase · Aminomuconate-semialdehyde dehydrogenase PHENYLALANINE→tyrosine→ (see below) G G→pyruvate →citrate glycine→serine→ Serine hydroxymethyltransferase · Serine dehydratase glycine→creatine: Guanidinoacetate N-methyltransferase · Creatine kinase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase G→glutamate→ α-ketoglutarate HISTIDINE→ Histidine ammonia-lyase · Urocanate hydratase · Formiminotransferase cyclodeaminase proline→ Proline oxidase · Pyrroline-5-carboxylate reductase · 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 · PYCR1 arginine→ Ornithine aminotransferase · Ornithine decarboxylase · Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase Other cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase · Glutathione synthetase · Gamma-glutamyl transpeptidase glutamate→glutamine: Glutamine synthetase · Glutaminase G→propionyl-CoA→ succinyl-CoA VALINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · Enoyl-CoA hydratase · 3-hydroxyisobutyryl-CoA hydrolase · 3-hydroxyisobutyrate dehydrogenase · Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ generation of homocysteine: Methionine adenosyltransferase · Adenosylhomocysteinase regeneration of methionine: MTR/Homocysteine methyltransferase · Betaine-homocysteine methyltransferase conversion to cysteine: Cystathionine beta synthase · Cystathionine gamma-lyase THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase · Methylmalonyl CoA epimerase · Methylmalonyl-CoA mutase G→fumarate PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase · Tyrosine aminotransferase · 4-Hydroxyphenylpyruvate dioxygenase · Homogentisate 1,2-dioxygenase · Fumarylacetoacetate hydrolase tyrosine→melanin: Tyrosinase G→oxaloacetate asparagine→aspartate→ Asparaginase/Asparagine synthetase · Aspartate transaminase see also disorders, intermediates