Aspartate—tRNA(Asn) ligase

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asparagine-tRNA(Asn) ligase
Identifiers
EC number 6.1.1.22
CAS number 9027-32-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an asparagine-tRNAAsn ligase (EC 6.1.1.22) is an enzyme that catalyzes the chemical reaction

ATP + L-asparagine + tRNAAsx \rightleftharpoons AMP + diphosphate + asparaginyl-tRNAAsx

The 3 substrates of this enzyme are ATP, L-asparagine, and tRNAAsx, whereas its 3 products are AMP, diphosphate, and asparaginyl-tRNAAsx.

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparaginyl:tRNAAsx ligase (AMP-forming). This enzyme is also called nondiscriminating asparaginyl-tRNA synthetase. This enzyme participates in alanine and asparagine metabolism.

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