Assisted zona hatching (AZH) is a procedure of assisted reproductive technology in which a small hole is made in the zona pellucida, using a micromanipulation, thereby facilitating for zona hatching to occur.[1][1] Zona hatching is where the blastocyst gets rid of the surrounding zona pellucida to be able to implant in the uterus.
Efficacy [edit]
A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos.[2] However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age.[2]
References [edit]
- ^ a b IVF-infertility.com
- ^ a b Martins, W. P.; Rocha, I. A.; Ferriani, R. A.; Nastri, C. O. (2011). "Assisted hatching of human embryos: A systematic review and meta-analysis of randomized controlled trials". Human Reproduction Update. doi:10.1093/humupd/dmr012. edit
