Asymmetric crying facies
|Asymmetric crying facies|
|Classification and external resources|
Asymmetric crying facies (ACF), also called Cayler cardiofacial syndrome, partial unilateral facial paresis and hypoplasia of depressor angula oris muscle, is a minor congenital anomaly caused by agenesis or hypoplasia of the depressor anguli oris muscle, one of the muscles that control the movements of the lower lip. This unilateral facial weakness is ﬁrst noticed when the infant cries or smiles, affecting only one corner of the mouth and occurs on the left side in nearly 80% of cases. It is associated with other birth defects in more than 50% of cases.
When the hypoplasia of the depressor anguli oris muscle is associated with congenital cardiac defects, the term 'Cayler cardiofacial syndrome' is used.
It was characterized by Cayler in 1969.
- Online 'Mendelian Inheritance in Man' (OMIM) 125520
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- Cayler GG (1969). "Cardiofacial syndrome. Congenital heart disease and facial weakness, a hitherto unrecognized association". Arch Dis Child 44 (233): 69–75. doi:10.1136/adc.44.233.69. PMC 2020193. PMID 5765991.
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