The firm has raised over $3.0 billion of investor commitments across its nine venture capital funds. The firm raised $705 million for its 2000-vintage fifth fund, $600 million for its 2001-vintage sixth fund, $385 million for its 2006-vintage seventh fund, and $283 million for its 2009-vintage eighth fund. The firm is currently investing from its ninth fund which closed in early 2013 with $265 million of capital. 
In 2009, Atlas significantly consolidated its investment operations and has been a proponent of the lean start-up approach in biotech. Partners Bruce Booth and Fred Destin both have blogs that have attracted a big following in their respective communities. At its largest, the firm had offices on the West Coast as well as in Europe. Today, the firm operates from a single office in Cambridge, Massachusetts.