|Classification and external resources|
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Atopic dermatitis (AD) also known as atopic eczema or eczema is a type of dermatitis, an inflammatory, relapsing, non-contagious and itchy skin disorder. It has been given names like "prurigo Besnier," "neurodermitis," "endogenous eczema," "flexural eczema," "infantile eczema," and "prurigo diathésique".
Signs and symptoms
People with AD often have dry and scaly skin that spans the entire body, except perhaps the diaper area, and intensely itchy red, splotchy, raised lesions to form in the bends of the arms or legs, face and neck. These lesions then weep, crack, swell and crust over. These lesions are at a heightened risk for bacterial, fungal or viral colonisation.
AD is generally considered idiopathic, that is, without a known cause. Although a genetic component is suspected, as is supported by the finding that many persons with AD have a family history of atopy, which are immediate-onset allergic reactions such as asthma, food allergies, AD or hay fever. In 2006 it was discovered that mutations in the gene for the production of filaggrin strongly increased the risk for developing atopic dermatitis. Most importantly two mutations were found that affect approximately 5% of people in Western Europe that may disrupt the production of filaggrin. Filaggrin is a protein that plays an important role in the retention of water in the stratum corneum. People who have these mutations often have dry skin. Those exposed to dogs while growing up have a lower risk of atopic dermatitis. There is also support from epidemiological studies for a protective role for helminths against AD. Likewise children with poor hygiene are at a lower risk for developing AD, as are children who drink unpasteurised milk. Exposure to dust mites are believed to contribute, to one's risk of developing AD. A diet high in fruits seems to have a protective effect against AD, whereas the opposite seems to be true for fast foods.
There is no known cure for AD, although treatments may reduce the severity and frequency of flares. Applying moisturisers may prevent the skin from drying out and decrease the need for other medications. Affected persons often report that improvement of skin hydration parallels with improvement in AD symptoms. Additionally topical corticosteroids, especially hydrocortisone have proven themselves effective in managing AD. If topical corticosteroids and moisturisers fail short-term treatment with topical calcineurin inhibitors like tacrolimus or pimecrolimus may be tried, although they are usually avoided as they can cause skin cancer or lymphoma. Alternatively systemic immunosuppressants may be tried such as ciclosporin, methotrexate, interferon gamma-1b, mycophenolate mofetil and azathioprine. Antidepressants and naltrexone may be used to control pruritus (itchiness).
A more novel form of treatment involves exposure to broad or narrow-band ultraviolet light. UV radiation exposure has been found to have a localized immunomodulatory effect on affected tissues and may be used to decrease the severity and frequency of flares. In particular, Meduri et al. have suggested that the usage of UVA1 is more effective in treating acute flares, whereas narrow-band UVB is more effective in long-term management scenarios. However, UV radiation has also been implicated in various types of skin cancer, and thus UV treatment is not without risk. Vitamin D has also proven itself an effective treatment for AD.
It is often recommended that persons with AD bathe regularly in lukewarm baths, especially in salt water, in order to moisten their skin. Avoiding woollen clothing is usually recommended for those with AD, likewise silk, silver-coated clothing is often recommended as a therapeutic measure against AD. Dilute bleach baths have also been reported effective at managing AD.
Since the beginning of the twentieth century, many mucosal inflammatory disorders have become more common; atopic eczema (AE) is a classic example of such a disease. It now affects 15-30% of children and 2-10% of adults in developed countries and in the United States has nearly tripled in the past thirty to forty years.
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