Atrasentan

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Atrasentan
Atrasentan.svg
Systematic (IUPAC) name
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
Clinical data
Legal status ?
Identifiers
CAS number 173937-91-2 N
ATC code None
PubChem CID 159594
ChemSpider 140321 YesY
UNII V6D7VK2215 YesY
ChEMBL CHEMBL9194 YesY
Chemical data
Formula C29H38N2O6 
Mol. mass 510.621 g/mol
 N (what is this?)  (verify)

Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer,[1] including non-small cell lung cancer.[2]

It is an endothelin receptor antagonist selective for subtype A (ETA). While other drugs of this type (sitaxentan, ambrisentan) exploit the vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation.

References[edit]

  1. ^ Atrasentan (entry in the public domain NCI Dictionary of Cancer Terms)
  2. ^ Chiappori, AA; Haura, E; Rodriguez, FA; Boulware, D; Kapoor, R; Neuger, AM; Lush, R; Padilla, B; Burton, M (1 March 2008). "Phase I/II Study of Atrasentan, an Endothelin A Receptor Antagonist, in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Advanced Non–Small Cell Lung Cancer". Clinical Cancer Research 14 (5): 1464–1469. doi:10.1158/1078-0432.CCR-07-1508. PMID 18316570.