He may have initially been trained by his father, Giovanni Battista Lomi, but soon he worked in Florence (1580-1590) under the painters Bronzino, then Lodovico Cardi (known as Cigoli). He was the nephew of the painter Baccio Lomi. He painted in Pisa, Florence, Rome, and Genoa. He painted a St. Jerome (1595) for the Duomo of Pisa. In addition he painted frescoes of San Frediano and San Stefano. He painted an altarpiece for Santa Apollonia. He painted a St. Anthony of Padua for the church of San Francesco di Casteletto in Genoa, and a Resurrection of Christ and Last Judgement for Santa Maria Assunta in Carignano. In Rome, he painted frescoes in the Pinelli chapel of Santa Maria in Vallicella, including Scenes from the life of the Virgin and Birth of Jesus on the arches, and the Dormition, Coronation, and Funeral of the Madonna on the vault. The walls are frescoed with Rebecca and Eleazar and Yael and Sisera.