Aluminon free acid
|Molar mass||422.34 g·mol−1|
|Appearance||Dark red to brown powder|
|Melting point||300 °C (572 °F; 573 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. It also inhibits apoptosis. It prevents down-regulation of Ca2+-impermeable GluR2 receptors and inhibits calpain, a Ca2+-activated protease that is activated during apoptosis.
It is used to inhibit protein biosynthesis in its initial stages. Nominally, it is used in biological experiments as a protein inhibitor, and as an ammonium salt (known as aluminon) it is used as a reagent to estimate the aluminium in water, biological tissue, and foods.
It has been discovered that using aurintricarboxylic acid against influenza-A post-infection has a strong protective effect by inhibiting the virus' ability to reproduce. In cultured canine kidney cells, it was found to reduce viral reproduction and infection when applied post-infection, but not when used as a 'vaccine'. It has also been shown to block the binding of the HIV coat molecule gp120 to the CD4 co-receptor on T cells through which it invades.
- "Aurintricarboxylic acid". Sigma-Aldrich.
- "Aurintricarboxylic Acid". Reference.MD.
- Skidmore, A. F.; Beebee, T. J. (October 1989). "Characterization and use of the potent ribonuclease inhibitor aurintricarboxylic acid for the isolation of RNA from animal tissues". The Biochemical Journal 263 (1): 73–80. PMC 1133392. PMID 2481441.
- Hashem, A. M.; Flaman, A. S.; Farnsworth, A.; Brown, E. G.; van Domselaar, G.; He, R.; Li, X. (2009). "Aurintricarboxylic Acid is a Potent Inhibitor of Influenza A and B Virus Neuraminidases". PLoS ONE 4 (12): e8350. doi:10.1371/journal.pone.0008350. PMC 2792043. PMID 20020057.
- Arthur I. Vogel. Practical Organic Chemistry Including Qualitative Organic Analysis.