Autotransplantation

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Autotransplantation
Intervention
MeSH D014182

Autotransplantation is the transplantation of organs, tissues, or even particular proteins from one part of the body to another in the same person (auto- = "self-"). The autologous tissue (also called autogenous, autogeneic, or autogenic tissue) transplanted by such a procedure is called an autograft or autotransplant. It is contrasted with xenotransplantation (from other species) and allotransplantation (from other individual of same species). A common example is when a piece of bone (usually from the hip) is removed and ground into a paste when reconstructing another portion of bone.

Autologous blood donation[edit]

In blood banking terminology, autologous blood donation refers to a blood donation marked for use by the donor, typically for a scheduled surgery. (Generally, the notion of "donation" does not refer to giving to one's self, though in this context it has become somewhat acceptably idiomatic.) They are commonly called "Autos" by blood bank personnel, and it is one major form of the more general concept of autotransfusion (the other being intraoperative blood salvage).

Some advantages of autologous blood donation are:

  • Blood type will always match, even with a rare blood type or antibody type.
  • If only autologous blood is used during surgery the risk of exposure to infectious disease such as hepatitis or HIV from blood is eliminated.
  • The risk of allergic reactions is reduced.

The disadvantages are:

  • Higher cost due to individualized processing, record-keeping, and management.
  • In most cases, the blood is discarded if it is not used instead of being added to the general supply.
  • Blood donation prior to colorectal cancer surgery seemed causative for a worse overall and colorectal cancer specific survival.[1]

Autologous blood is not routinely tested for infectious diseases markers such as HIV antibodies. In the United States, autologous blood is tested only if it is collected in one place and shipped to another.

There is also a risk that, in an emergency or if more blood is required than has been set aside in advance, the patient could still be exposed to donor blood instead of autologous blood. Autologous donation is also not suitable for patients who are medically unable to or advised not to give blood, such as cardiac patients or small children and infants.

Bone autograft[edit]

Illustration depicting bone autograft.

In orthopaedic medicine, bone graft can be sourced from a patient's own bone in order to fill space and produce an osteogenic response in a bone defect. However, due to the donor-site morbidity associated with autograft, other methods such as bone allograft and bone morphogenetic proteins and synthetic graft materials are often used as alternatives. Autografts have long been considered the "Gold Standard" in Oral Surgery and Implant Dentistry because it offered the best regenerations results. Lately, the introduction of morphogen-enhanced bone graft substitutes have shown to show similar success rates and quality of regeneration; however, their price is still very high.

Autologous organ graft[edit]

Recent advances in decellularization have allowed researchers to recreate an organ using a patient's own tissue cells that are grafted on an allograft protein scaffold.[2]

See also[edit]

  • Autotransfusion - the process of returning to a patient their own blood that has been lost.
  • Replantation - reattaching a severed limb or other part of the body.
  • Rotationplasty - attaching the foot with ankle joint (reversed) to the femur to replace the knee.

External links[edit]

References[edit]

  1. ^ Harlaar, JJ; Gosselink, MP; Hop, WC; Lange, JF; Busch, OR; Jeekel, H (November 2012). "Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial.". Annals of surgery 256 (5): 681–7. doi:10.1097/SLA.0b013e318271cedf. PMID 23095610. 
  2. ^ http://video.nationalgeographic.com/video/national-geographic-channel/full-episodes/explorer/ngc-how-to-build-a-beating-heart/