Autoimmune enteropathy

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Autoimmune enteropathy is a rare condition that happens usually to infants, young children and sometimes adults make them to have several diarrheas and sometimes so much that the children need intravenous fluids. Food and vitamins are also be effected because the body attacks to the own intestinal wall, irritating the lining of the intestine. Sometimes it attacks to others places as thyroid or others glands in the body or kidneys.


Symptoms[edit]

The main symptoms of Autoimmune enteropathy include:

Types[edit]

There are 3 types of autoimmune enteropathy:

Type 1: IPEX syndrome: Immune dysregulation, Polyendocrinopathy, Enteropathy, X – linked syndrome.

Type 2: IPEX - like but without mutations in the FOXP3 gene.

Type 3: Autoimmune manifestations primarily limited to the GI tract.

As to many immune diseases, the autoimmune enteropathy can be effected by others autoimmune disorders leading to specific forms as IPEX and APECED.

Diagnosis[edit]

In order to a person to be positive in the autoimmune enteropathy is to do a diagnostic test and find positive one of the IgG, IgA or IgM antibody against the enterocyte. The diagnostic test contains the Western Blot which can identify the antibody IgG or IgA and with the immunohistochemistry we can localize these antibodies.

Treatment[edit]

The treatment is usually medicines that suppress the immune system. The children also may need intravenous nutrition and a special diet. The surgery, in many cases, is not needed.

References[edit]

^ http://www.ncbi.nlm.nih.gov/pubmed/19255930, D'Onofrio, F., Gallo, A., Gasbarrini, A., Gasbarrini, G., Montalto, M., Santoro, L. (2009).Autoimmune Enteropathy in Children and Adults. Institute of Internal Medicine, Vol.44(9), p. 1029 - 1036.

^http://www.cincinnatichildrens.org/health/a/autoimmune-enteropathy/, Autoimmune Enteropathy. Cincinnati Children's, (1999 - 2013), Ohio.

^ http://www.rightdiagnosis.com/a/autoimmune_enteropathy/intro.htm, Autoimmune Enteropathy. Right Diagnosis, Last Update 7 May 2013.

^ http://www.naspghan.org/, Harland S. Winter (2010): Autoimmune Enteropathy: My Infant Patient Has Intractable Diarrhea. Boston,MA: Harvard Medical School.