His main area of research is the development of solid-state NMR and its applications to non-soluble, non-crystalline chemical and biological solids. He is known for the development of solid-state NMR methods (such as USEME, PISEMA, PITANSEMA, HIMSELF, etc.) and as a researcher of membrane-associated peptides and proteins, an organizer of international symposia, and author of a book on NMR Spectroscopy of biological solids. He was also involved in the characterization of new nanomaterials. He teaches Chemistry, Biophysics and NMR to undergraduate and graduate students at the University of Michigan.
Xu J, Struppe J, Ramamoorthy A. Two-dimensional homonuclear chemical shift correlation established by the cross-relaxation driven spin diffusion in solids. J. Chem. Phys. 128 (2008) 052308.
Dürr UHN, Yamamoto K, Im SC, Waskell L, Ramamoorthy A, Solid-State NMR Reveals Structural and Dynamical Properties of a Membrane-Anchored Electron-Carrier Protein, Cytochrome b(5), J. Am. Chem. Soc. 129 (2007) 6670-6671.
Dürr UHN, Waskell L, Ramamoorthy A. The cytochromes P450 and b5 and their reductases-Promising targets for structural studies by advanced solid-state NMR spectroscopy, Biochim. Biophys. Acta. 1768 (2007) 3235-3259.