Azelnidipine

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Azelnidipine
Azelnidipine.png
Systematic (IUPAC) name
O3-[1-[di(phenyl)methyl]azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number 123524-52-7 N
ATC code None
PubChem CID 65948
ChemSpider 59352 YesY
UNII PV23P19YUG YesY
KEGG D01145 YesY
ChEMBL CHEMBL1275868 N
Chemical data
Formula C33H34N4O6 
Mol. mass 582.64 g/mol
 N (what is this?)  (verify)

Azelnidipine (INN; marketed under the brand name Calblock) is a dihydropyridine calcium channel blocker. It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.[1]

Synthesis[edit]

N.B. See art of drug synthesis for further detailed info.

Koike, H., Nishino, H., and Yoshimoto, M. (1988). “Dihydropyridine derivatives, their preparation and their use,” U.S. Patent 4,772,596 (to Sankyo Company Limited and Ube Industries Limited).

References[edit]

  1. ^ Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker" ([dead link]Scholar search). Jpn. J. Pharmacol. 51 (1): 57–64. doi:10.1254/jjp.51.57. PMID 2810942.