Azilsartan

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Azilsartan medoxomil
Azilsartan.svg
Systematic (IUPAC) name
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-carboxylate
Clinical data
Trade names Edarbi
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a611028
Licence data US FDA:link
Pregnancy cat.
  • C (1st trimester)
    D (2nd/3rd trimester) (US)
Legal status
Routes Oral
Identifiers
CAS number 147403-03-0 N
ATC code C09CA09
PubChem CID 9825285
ChemSpider 9413866 YesY
UNII F9NUX55P23 YesY
ChEBI CHEBI:68845 N
ChEMBL CHEMBL57242 N
Chemical data
Formula C25H20N4O5 
Mol. mass 456,46 g/mol
 N (what is this?)  (verify)

Azilsartan (INN, codenamed TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension that was developed by Takeda.

It is marketed in tablet form under the trade name Edarbi as the prodrug azilsartan medoxomil (INN, codenamed TAK-491). On 25 February 2011, the U.S. Food and Drug Administration (FDA) approved azilsartan medoxomil for the treatment of high blood pressure in adults.[1] On March 8, 2012, Health Canada approved the drug for mild to moderate essential hypertension. [2]

Mechanism of action[edit]

Azilsartan medoxomil lowers blood pressure by blocking the action of angiotensin II, a vasopressor hormone.

Azilsartan medoxomil, the prodrug used, ‘Edarbi’

References[edit]