Azlocillin

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Azlocillin
Azlocillin skeletal.svg
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 37091-66-0 YesY
ATC code J01CA09
PubChem CID 6479523
DrugBank DB01061
ChemSpider 4980416 YesY
UNII HUM6H389W0 YesY
KEGG D02339 YesY
ChEBI CHEBI:2956 YesY
ChEMBL CHEMBL1537 YesY
Chemical data
Formula C20H23N5O6S 
Mol. mass 461.491 g/mol
 YesY (what is this?)  (verify)

Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa and, in contrast to most cephalosporins, exhibits activity against enterococci.

Spectrum of bacterial susceptibility[edit]

Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative bacteria. The following represents MIC susceptibility data for a few medically significant organisms.[1]

  • Escherichia coli 1 μg/mL - 32 μg/mL
  • Haemophilus spp. 0.03 μg/mL - 2 μg/mL
  • Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL

References[edit]