B3GALT4

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UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Identifiers
Symbols B3GALT4 ; BETA3GALT4; GALT2; GALT4
External IDs OMIM603095 MGI1859517 HomoloGene2805 GeneCards: B3GALT4 Gene
EC number 2.4.1.62
RNA expression pattern
PBB GE B3GALT4 210205 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8705 54218
Ensembl ENSG00000206285 ENSMUSG00000067370
UniProt O96024 Q9Z0F0
RefSeq (mRNA) NM_003782 NM_019420
RefSeq (protein) NP_003773 NP_062293
Location (UCSC) Chr 6:
33.24 – 33.25 Mb
Chr 17:
33.95 – 33.95 Mb
PubMed search [1] [2]

Beta-1,3-galactosyltransferase 4 is an enzyme that in humans is encoded by the B3GALT4 gene.[1][2]

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis.[2]

References[edit]

  1. ^ Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H (Jun 1998). "A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family". J Biol Chem 273 (21): 12770–8. doi:10.1074/jbc.273.21.12770. PMID 9582303. 
  2. ^ a b "Entrez Gene: B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4". 

Further reading[edit]