B3GALT5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Identifiers
Symbols B3GALT5 ; B3GalT-V; B3GalTx; B3T5; GLCT5; beta3Gal-T5
External IDs OMIM604066 MGI2136878 HomoloGene13230 GeneCards: B3GALT5 Gene
RNA expression pattern
PBB GE B3GALT5 206947 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10317 93961
Ensembl ENSG00000183778 ENSMUSG00000074892
UniProt Q9Y2C3 Q9JI67
RefSeq (mRNA) NM_006057 NM_001122993
RefSeq (protein) NP_006048 NP_001116465
Location (UCSC) Chr 21:
40.93 – 41.03 Mb
Chr 16:
96.24 – 96.32 Mb
PubMed search [1] [2]

Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.[1][2]

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein.[2]

References[edit]

  1. ^ Isshiki S, Togayachi A, Kudo T, Nishihara S, Watanabe M, Kubota T, Kitajima M, Shiraishi N, Sasaki K, Andoh T, Narimatsu H (Jun 1999). "Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom". J Biol Chem 274 (18): 12499–507. doi:10.1074/jbc.274.18.12499. PMID 10212226. 
  2. ^ a b "Entrez Gene: B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5". 

Further reading[edit]

External links[edit]