B3GAT3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Protein B3GAT3 PDB 1fgg.png
PDB rendering based on 1fgg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols B3GAT3 ; GLCATI
External IDs OMIM606374 MGI1919977 HomoloGene56554 ChEMBL: 3958 GeneCards: B3GAT3 Gene
EC number 2.4.1.135
RNA expression pattern
PBB GE B3GAT3 35179 at tn.png
PBB GE B3GAT3 203452 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26229 72727
Ensembl ENSG00000149541 ENSMUSG00000071649
UniProt O94766 P58158
RefSeq (mRNA) NM_012200 NM_024256
RefSeq (protein) NP_036332 NP_077218
Location (UCSC) Chr 11:
62.38 – 62.39 Mb
Chr 19:
8.92 – 8.93 Mb
PubMed search [1] [2]

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.[1][2]

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.[2]

References[edit]

  1. ^ Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (Apr 1998). "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem 273 (12): 6615–8. doi:10.1074/jbc.273.12.6615. PMID 9506957. 
  2. ^ a b "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 

Further reading[edit]