B4GALNT1

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Beta-1,4-N-acetyl-galactosaminyl transferase 1
Identifiers
Symbols B4GALNT1 ; GALGT; GALNACT; GalNAc-T
External IDs OMIM601873 MGI1342057 HomoloGene1133 GeneCards: B4GALNT1 Gene
EC number 2.4.1.92
RNA expression pattern
PBB GE B4GALNT1 206435 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2583 14421
Ensembl ENSG00000135454 ENSMUSG00000006731
UniProt Q00973 Q09200
RefSeq (mRNA) NM_001276468 NM_001244617
RefSeq (protein) NP_001263397 NP_001231546
Location (UCSC) Chr 12:
58.02 – 58.03 Mb
Chr 10:
127.17 – 127.17 Mb
PubMed search [1] [2]

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.[1][2]

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.[2]

References[edit]

  1. ^ Nagata Y, Yamashiro S, Yodoi J, Lloyd KO, Shiku H, Furukawa K (Jul 1992). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides". J Biol Chem 267 (17): 12082–9. PMID 1601877. 
  2. ^ a b "Entrez Gene: B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1". 

Further reading[edit]