B4GALNT2
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| Beta-1,4-N-acetyl-galactosaminyl transferase 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | B4GALNT2; B4GALT; GALGT2; MGC142235; MGC142237 | ||||||||||||
| External IDs | OMIM: 111730 MGI: 1342058 HomoloGene: 7329 GeneCards: B4GALNT2 Gene | ||||||||||||
| EC number | 2.4.1.- | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 124872 | 14422 | |||||||||||
| Ensembl | ENSG00000167080 | ENSMUSG00000013418 | |||||||||||
| UniProt | Q8NHY0 | Q9Z2F4 | |||||||||||
| RefSeq (mRNA) | NM_001159387.1 | NM_008081.3 | |||||||||||
| RefSeq (protein) | NP_001152859.1 | NP_032107.1 | |||||||||||
| Location (UCSC) | Chr 17: 47.21 – 47.25 Mb |
Chr 11: 95.73 – 95.78 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Beta-1,4 N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the B4GALNT2 gene.[1][2][3]
[edit] References
- ^ Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Oct 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". Int J Cancer 67 (5): 626–31. doi:10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W. PMID 8782649.
- ^ Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". Biochem J 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490. PMID 12678917. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223490.
- ^ "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124872.
[edit] Further reading
- Berger EG (2002). "Ectopic localizations of Golgi glycosyltransferases". Glycobiology 12 (2): 29R–36R. doi:10.1093/glycob/12.2.29R. PMID 11886838.
- Wang HR, Hsieh CY, Twu YC, Yu LC (2008). "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status". Glycobiology 18 (1): 104–13. doi:10.1093/glycob/cwm120. PMID 17965433.
- Kawamura YI, Kawashima R, Fukunaga R et al (2005). "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Res. 65 (14): 6220–7. doi:10.1158/0008-5472.CAN-05-0639. PMID 16024623.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F (2004). "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain". J. Biochem. 134 (5): 675–82. doi:10.1093/jb/mvg192. PMID 14688233.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Piller F, Blanchard D, Huet M, Cartron JP (1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney". Carbohydr. Res. 149 (1): 171–84. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
- Li PT, Liao CJ, Wu WG, Yu LC, Chu ST (June 2011). "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice". Fertil. Steril. 95 (7): 2404–9, 2409.e1–3. doi:10.1016/j.fertnstert.2011.03.043. PMID 21481371.
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