B4GALT2

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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Identifiers
Symbols B4GALT2 ; B4Gal-T2; B4Gal-T3; beta4Gal-T2
External IDs OMIM604013 MGI1858493 HomoloGene2804 GeneCards: B4GALT2 Gene
EC number 2.4.1.22, 2.4.1.38, 2.4.1.90
RNA expression pattern
PBB GE B4GALT2 209413 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8704 53418
Ensembl ENSG00000117411 ENSMUSG00000028541
UniProt O60909 Q9Z2Y2
RefSeq (mRNA) NM_001005417 NM_001253381
RefSeq (protein) NP_001005417 NP_001240310
Location (UCSC) Chr 1:
44.44 – 44.46 Mb
Chr 4:
117.87 – 117.88 Mb
PubMed search [1] [2]

Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.[1][2][3]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Two transcript variants encoding the same protein have been found for this gene.[3]

References[edit]

  1. ^ Almeida R, Amado M, David L, Levery SB, Holmes EH, Merkx G, van Kessel AG, Rygaard E, Hassan H, Bennett E, Clausen H (Jan 1998). "A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3". J Biol Chem 272 (51): 31979–91. doi:10.1074/jbc.272.51.31979. PMID 9405390. 
  2. ^ Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550. 
  3. ^ a b "Entrez Gene: B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2". 

Further reading[edit]