B4GALT3

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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Identifiers
Symbols B4GALT3 ; beta4Gal-T3
External IDs OMIM604014 MGI1928767 HomoloGene48241 GeneCards: B4GALT3 Gene
EC number 2.4.1.38, 2.4.1.90
RNA expression pattern
PBB GE B4GALT3 210243 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8703 57370
Ensembl ENSG00000158850 ENSMUSG00000052423
UniProt O60512 Q91YY2
RefSeq (mRNA) NM_001199873 NM_020579
RefSeq (protein) NP_001186802 NP_065604
Location (UCSC) Chr 1:
161.14 – 161.15 Mb
Chr 1:
171.27 – 171.28 Mb
PubMed search [1] [2]

Beta-1,4-galactosyltransferase 3 is an enzyme that in humans is encoded by the B4GALT3 gene.[1][2][3]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains.[3]

References[edit]

  1. ^ Almeida R, Amado M, David L, Levery SB, Holmes EH, Merkx G, van Kessel AG, Rygaard E, Hassan H, Bennett E, Clausen H (Jan 1998). "A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3". J Biol Chem 272 (51): 31979–91. doi:10.1074/jbc.272.51.31979. PMID 9405390. 
  2. ^ Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550. 
  3. ^ a b "Entrez Gene: B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3". 

Further reading[edit]