B4GALT5

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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
Identifiers
Symbols B4GALT5 ; B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5; beta4GalT-V; gt-V
External IDs OMIM604016 MGI1927169 HomoloGene3507 GeneCards: B4GALT5 Gene
EC number 2.4.1.38
RNA expression pattern
PBB GE B4GALT5 221485 at tn.png
PBB GE B4GALT5 221484 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9334 56336
Ensembl ENSG00000158470 ENSMUSG00000017929
UniProt O43286 Q9JMK0
RefSeq (mRNA) NM_004776 NM_019835
RefSeq (protein) NP_004767 NP_062809
Location (UCSC) Chr 20:
48.25 – 48.33 Mb
Chr 2:
167.3 – 167.35 Mb
PubMed search [1] [2]

Beta-1,4-galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene.[1][2][3]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.[3]

References[edit]

  1. ^ Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550. 
  2. ^ Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I (Feb 1998). "Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase". Proc Natl Acad Sci U S A 95 (2): 472–7. doi:10.1073/pnas.95.2.472. PMC 18444. PMID 9435216. 
  3. ^ a b "Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5". 

Further reading[edit]