BAAT

Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
Identifiers
Symbols	BAAT; BACAT; BAT; FLJ20300; MGC104432
External IDs	OMIM: 602938 MGI: 106642 HomoloGene: 1286 GeneCards: BAAT Gene
Gene Ontology Molecular function • carboxylesterase activity • acyltransferase activity • acyltransferase activity • palmitoyl-CoA hydrolase activity • N-acyltransferase activity • transferase activity • hydrolase activity • thiolester hydrolase activity • glycine N-choloyltransferase activity Cellular component • cytoplasm • peroxisome • peroxisomal matrix • cytosol • intracellular membrane-bounded organelle Biological process • glycine metabolic process • lipid metabolic process • fatty acid metabolic process • acyl-CoA metabolic process • bile acid biosynthetic process • digestion • bile acid metabolic process • bile acid and bile salt transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	570	12012
Ensembl	ENSG00000136881	ENSMUSG00000039653
UniProt	Q14032	Q91X34
RefSeq (mRNA)	NM_001127610.1	NM_007519.3
RefSeq (protein)	NP_001121082.1	NP_031545.2
Location (UCSC)	Chr 9: 104.12 – 104.15 Mb	Chr 4: 49.5 – 49.52 Mb
PubMed search	[1]	[2]

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.

Further reading

• Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.". J. Biol. Chem. 266 (16): 10227–33. PMID 2037576. 
• Falany CN, Johnson MR, Barnes S, Diasio RB (1994). "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.". J. Biol. Chem. 269 (30): 19375–9. PMID 8034703. 
• Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3.". Genomics 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802. 
• Solaas K, Ulvestad A, Söreide O, Kase BF (2000). "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts.". J. Lipid Res. 41 (7): 1154–62. PMID 10884298. 
• Sfakianos MK, Wilson L, Sakalian M, et al. (2003). "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase.". J. Biol. Chem. 277 (49): 47270–5. doi:10.1074/jbc.M207463200. PMID 12239217. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Carlton VE, Harris BZ, Puffenberger EG, et al. (2003). "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.". Nat. Genet. 34 (1): 91–6. doi:10.1038/ng1147. PMID 12704386. 
• Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.". Biochem. Biophys. Res. Commun. 305 (3): 611–8. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038. 
• O'Byrne J, Hunt MC, Rai DK, et al. (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.". J. Biol. Chem. 278 (36): 34237–44. doi:10.1074/jbc.M300987200. PMID 12810727. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Pellicoro A, van den Heuvel FA, Geuken M, et al. (2007). "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport.". Hepatology 45 (2): 340–8. doi:10.1002/hep.21528. PMID 17256745. 
• Tougou K, Fukuda T, Ito T, et al. (2007). "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.". Drug Metab. Pharmacokinet. 22 (2): 125–8. doi:10.2133/dmpk.22.125. PMID 17495420.