BAG1
From Wikipedia, the free encyclopedia
| BCL2-associated athanogene | |||||||||||||
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 PDB rendering based on 1hx1. |
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| Identifiers | |||||||||||||
| Symbols | BAG1; HAP; RAP46 | ||||||||||||
| External IDs | OMIM: 601497 MGI: 108047 HomoloGene: 3190 GeneCards: BAG1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 573 | 12017 | |||||||||||
| Ensembl | ENSG00000107262 | ENSMUSG00000028416 | |||||||||||
| UniProt | Q99933 | Q6IS45 | |||||||||||
| RefSeq (mRNA) | NM_001172415.1 | NM_009736 | |||||||||||
| RefSeq (protein) | NP_001165886.1 | NP_033866 | |||||||||||
| Location (UCSC) | Chr 9: 33.24 – 33.25 Mb |
Chr 4: 40.88 – 40.9 Mb |
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| PubMed search | [1] | [2] | |||||||||||
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.[1]
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[2]
BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively [3] [4].
[edit] Interactions
BAG1 has been shown to interact with Retinoic acid receptor alpha,[5] C-Raf,[6] PPP1R15A,[7] Androgen receptor,[8][9][10] HSPA8,[11][12] Heparin-binding EGF-like growth factor,[13] Glucocorticoid receptor,[14][15] Calcitriol receptor[16] and SIAH1.[17]
[edit] References
- ^ Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (Mar 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
- ^ "Entrez Gene: BAG1 BCL2-associated athanogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573.
- ^ Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C. 2009. EMBO J. 28(7):889-901.
- ^ Physorg:Old Cells Work Differently
- ^ Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul. 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. doi:10.1074/jbc.273.27.16985. ISSN 0021-9258. PMID 9642262.
- ^ Wang, H G; Takayama S, Rapp U R, Reed J C (Jul. 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (14): 7063–8. doi:10.1073/pnas.93.14.7063. ISSN 0027-8424. PMC 38936. PMID 8692945. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38936.
- ^ Hung, Wesley J; Roberson Rachel S, Taft Jaime, Wu Daniel Y (May. 2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. (United States) 23 (10): 3477–86. doi:10.1128/MCB.23.10.3477-3486.2003. ISSN 0270-7306. PMC 164759. PMID 12724406. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164759.
- ^ Shatkina, Liubov; Mink Sigrun, Rogatsch Hermann, Klocker Helmut, Langer Gernot, Nestl Andrea, Cato Andrew C B (Oct. 2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. (United States) 23 (20): 7189–97. doi:10.1128/MCB.23.20.7189-7197.2003. ISSN 0270-7306. PMC 230325. PMID 14517289. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230325.
- ^ Knee, D A; Froesch B A, Nuber U, Takayama S, Reed J C (Apr. 2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. (United States) 276 (16): 12718–24. doi:10.1074/jbc.M010841200. ISSN 0021-9258. PMID 11278763.
- ^ Froesch, B A; Takayama S, Reed J C (May. 1998). "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. (UNITED STATES) 273 (19): 11660–6. doi:10.1074/jbc.273.19.11660. ISSN 0021-9258. PMID 9565586.
- ^ Takayama, S; Bimston D N, Matsuzawa S, Freeman B C, Aime-Sempe C, Xie Z, Morimoto R I, Reed J C (Aug. 1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. (ENGLAND) 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. ISSN 0261-4189. PMC 1170124. PMID 9305631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170124.
- ^ Takayama, S; Xie Z, Reed J C (Jan. 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. (UNITED STATES) 274 (2): 781–6. doi:10.1074/jbc.274.2.781. ISSN 0021-9258. PMID 9873016.
- ^ Lin, J; Hutchinson L, Gaston S M, Raab G, Freeman M R (Aug. 2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. (United States) 276 (32): 30127–32. doi:10.1074/jbc.M010237200. ISSN 0021-9258. PMID 11340068.
- ^ Kullmann, M; Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato A C (Jun. 1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. (UNITED STATES) 273 (23): 14620–5. doi:10.1074/jbc.273.23.14620. ISSN 0021-9258. PMID 9603979.
- ^ Schneikert, J; Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato A C (Dec. 2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. (ENGLAND) 19 (23): 6508–16. doi:10.1093/emboj/19.23.6508. ISSN 0261-4189. PMC 305849. PMID 11101523. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305849.
- ^ Guzey, M; Takayama S, Reed J C (Dec. 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. (UNITED STATES) 275 (52): 40749–56. doi:10.1074/jbc.M004977200. ISSN 0021-9258. PMID 10967105.
- ^ Matsuzawa, S; Takayama S, Froesch B A, Zapata J M, Reed J C (May. 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. (ENGLAND) 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. ISSN 0261-4189. PMC 1170614. PMID 9582267. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170614.
[edit] Further reading
- Tang SC (2003). "BAG-1, an anti-apoptotic tumour marker.". IUBMB Life 53 (2): 99–105. doi:10.1080/15216540211473. PMID 12049201.
- Clemo NK, Arhel NJ, Barnes JD, et al. (2005). "The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.". Biochem. Soc. Trans. 33 (Pt 4): 676–8. doi:10.1042/BST0330676. PMID 16042572.
- Gehring U (2007). "Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms.". Cell Stress Chaperones 11 (4): 295–303. doi:10.1379/1466-1268(2006)11[295:AOTCBA]2.0.CO;2. PMC 1712677. PMID 17278878. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1712677.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Zeiner M, Gehring U (1996). "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11465–9. doi:10.1073/pnas.92.25.11465. PMC 40422. PMID 8524784. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40422.
- Wang HG, Takayama S, Rapp UR, Reed JC (1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. doi:10.1073/pnas.93.14.7063. PMC 38936. PMID 8692945. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38936.
- Takayama S, Kochel K, Irie S, et al. (1996). "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.". Genomics 35 (3): 494–8. doi:10.1006/geno.1996.0389. PMID 8812483.
- Bardelli A, Longati P, Albero D, et al. (1997). "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.". EMBO J. 15 (22): 6205–12. PMC 452442. PMID 8947043. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452442.
- Takayama S, Bimston DN, Matsuzawa S, et al. (1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70.". EMBO J. 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. PMC 1170124. PMID 9305631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170124.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Packham G, Brimmell M, Cleveland JL (1998). "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.". Biochem. J.. 328 ( Pt 3): 807–13. PMC 1218990. PMID 9396724. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218990.
- Matsuzawa S, Takayama S, Froesch BA, et al. (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.". EMBO J. 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. PMC 1170614. PMID 9582267. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170614.
- Kullmann M, Schneikert J, Moll J, et al. (1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis.". J. Biol. Chem. 273 (23): 14620–5. doi:10.1074/jbc.273.23.14620. PMID 9603979.
- Liu R, Takayama S, Zheng Y, et al. (1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.". J. Biol. Chem. 273 (27): 16985–92. doi:10.1074/jbc.273.27.16985. PMID 9642262.
- Takayama S, Krajewski S, Krajewska M, et al. (1998). "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.". Cancer Res. 58 (14): 3116–31. PMID 9679980.
- Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
- Yang X, Pater A, Tang SC (1999). "Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.". Oncogene 18 (32): 4546–53. doi:10.1038/sj.onc.1202843. PMID 10467399.
- Schneikert J, Hübner S, Martin E, Cato AC (1999). "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.". J. Cell Biol. 146 (5): 929–40. doi:10.1083/jcb.146.5.929. PMC 2169481. PMID 10477749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169481.
- Lüders J, Demand J, Höhfeld J (2000). "The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.". J. Biol. Chem. 275 (7): 4613–7. doi:10.1074/jbc.275.7.4613. PMID 10671488.
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