From Wikipedia, the free encyclopedia
Jump to: navigation, search
BAI1-associated protein 2
Protein BAIAP2 PDB 1wdz.png
PDB rendering based on 1wdz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BAIAP2 ; BAP2; FLAF3; IRSP53
External IDs OMIM605475 MGI2137336 HomoloGene9697 GeneCards: BAIAP2 Gene
RNA expression pattern
PBB GE BAIAP2 207832 at tn.png
PBB GE BAIAP2 209502 s at tn.png
PBB GE BAIAP2 205294 at tn.png
More reference expression data
Species Human Mouse
Entrez 10458 108100
Ensembl ENSG00000175866 ENSMUSG00000025372
UniProt Q9UQB8 Q8BKX1
RefSeq (mRNA) NM_001144888 NM_001037754
RefSeq (protein) NP_001138360 NP_001032843
Location (UCSC) Chr 17:
79.01 – 79.09 Mb
Chr 11:
119.94 – 120.01 Mb
PubMed search [1] [2]

Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene.[1][2]


The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function.[2]


BAIAP2 has been shown to interact with:


  1. ^ Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T (June 1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenet Cell Genet 84 (1–2): 75–82. doi:10.1159/000015219. PMID 10343108. 
  2. ^ a b "Entrez Gene: BAIAP2 BAI1-associated protein 2". 
  3. ^ Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (June 1999). "Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate". Hum. Mol. Genet. 8 (6): 947–57. doi:10.1093/hmg/8.6.947. PMID 10332026. 
  4. ^ a b c d Miki H, Yamaguchi H, Suetsugu S, Takenawa T (Dec 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature 408 (6813): 732–5. doi:10.1038/35047107. PMID 11130076. 
  5. ^ a b Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591. 
  6. ^ Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A (October 2001). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H (August 2004). "IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness". Cancer Res. 64 (15): 5237–44. doi:10.1158/0008-5472.CAN-04-0327. PMID 15289329. 

Further reading[edit]