BAMBI

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This article is about the human gene. For the German media award, see Bambi award. For other uses, see Bambi (disambiguation).
BMP and activin membrane-bound inhibitor
Identifiers
Symbols BAMBI ; NMA
External IDs OMIM604444 MGI1915260 HomoloGene8215 GeneCards: BAMBI Gene
Orthologs
Species Human Mouse
Entrez 25805 68010
Ensembl ENSG00000095739 ENSMUSG00000024232
UniProt Q13145 Q9D0L6
RefSeq (mRNA) NM_012342 NM_026505
RefSeq (protein) NP_036474 NP_080781
Location (UCSC) Chr 10:
28.97 – 28.97 Mb
Chr 18:
3.51 – 3.52 Mb
PubMed search [1] [2]

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[1][2]

Function[edit]

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[1]

References[edit]

  1. ^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)". 
  2. ^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.