BCAM

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Basal cell adhesion molecule (Lutheran blood group)
Protein BCAM PDB 2PET.png
Rendering based on PDB 2PET.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCAM ; AU; CD239; LU; MSK19
External IDs OMIM612773 MGI1929940 HomoloGene21149 GeneCards: BCAM Gene
RNA expression pattern
PBB GE BCAM 40093 at tn.png
PBB GE BCAM 203009 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4059 57278
Ensembl ENSG00000187244 ENSMUSG00000002980
UniProt P50895 Q9R069
RefSeq (mRNA) NM_001013257 NM_020486
RefSeq (protein) NP_001013275 NP_065232
Location (UCSC) Chr 19:
45.31 – 45.32 Mb
Chr 7:
19.76 – 19.77 Mb
PubMed search [1] [2]

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene.[1] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function[edit]

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions[edit]

BCAM has been shown to interact with Laminin, alpha 5.[2][3]

References[edit]

  1. ^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)". 
  2. ^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. 
  3. ^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.