BCAP31

B-cell receptor-associated protein 31
Identifiers
Symbols	BCAP31; 6C6-AG; BAP31; CDM; DXS1357E
External IDs	OMIM: 300398 MGI: 1350933 HomoloGene: 38095 GeneCards: BCAP31 Gene
Gene Ontology Molecular function • receptor binding • protein binding Cellular component • Golgi membrane • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • plasma membrane • integral to plasma membrane • ER-Golgi intermediate compartment membrane Biological process • intracellular protein transport • apoptosis • cellular component disassembly involved in apoptosis • immune response • spermatogenesis • vesicle-mediated transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10134	27061
Ensembl	ENSG00000185825	ENSMUSG00000002015
UniProt	P51572	Q3U9U5
RefSeq (mRNA)	NM_001139441.1	NM_012060.4
RefSeq (protein)	NP_001132913.1	NP_036190.2
Location (UCSC)	Chr X: 152.97 – 152.99 Mb	Chr X: 70.93 – 70.96 Mb
PubMed search	[1]	[2]

B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.

Interactions

BCAP31 has been shown to interact with Caspase 8, VAMP3, BCL2-like 1, Bcl-2 and Amyloid precursor protein.

Further reading

• Mosser J, Sarde CO, Vicaire S, et al. (1995). "A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene.". Genomics 22 (2): 469–71. doi:10.1006/geno.1994.1413. PMID 7806238. 
• Sora I, Richman J, Santoro G, et al. (1994). "The cloning and expression of a human creatine transporter.". Biochem. Biophys. Res. Commun. 204 (1): 419–27. doi:10.1006/bbrc.1994.2475. PMID 7945388. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Adachi T, Schamel WW, Kim KM, et al. (1996). "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence.". EMBO J. 15 (7): 1534–41. PMC 450061. PMID 8612576. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450061. 
• Li E, Bestagno M, Burrone O (1996). "Molecular cloning and characterization of a transmembrane surface antigen in human cells.". Eur. J. Biochem. 238 (3): 631–8. doi:10.1111/j.1432-1033.1996.0631w.x. PMID 8706661. 
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695. 
• Ng FW, Nguyen M, Kwan T, et al. (1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.". J. Cell Biol. 139 (2): 327–38. doi:10.1083/jcb.139.2.327. PMC 2139787. PMID 9334338. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139787. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132629. 
• Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria.". Mol. Cell. Biol. 20 (18): 6731–40. doi:10.1128/MCB.20.18.6731-6740.2000. PMC 86192. PMID 10958671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86192. 
• Bell AW, Ward MA, Blackstock WP, et al. (2001). "Proteomics characterization of abundant Golgi membrane proteins.". J. Biol. Chem. 276 (7): 5152–65. doi:10.1074/jbc.M006143200. PMID 11042173. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Spiliotis ET, Manley H, Osorio M, et al. (2001). "Selective export of MHC class I molecules from the ER after their dissociation from TAP.". Immunity 13 (6): 841–51. doi:10.1016/S1074-7613(00)00081-9. PMID 11163199. 
• Manley HA, Lennon VA (2001). "Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells.". J. Histochem. Cytochem. 49 (10): 1235–43. PMID 11561007. 
• Zuppini A, Groenendyk J, Cormack LA, et al. (2002). "Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis.". Biochemistry 41 (8): 2850–8. doi:10.1021/bi015967. PMID 11851433. 
• Breckenridge DG, Nguyen M, Kuppig S, et al. (2002). "The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4331–6. doi:10.1073/pnas.072088099. PMC 123648. PMID 11917123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=123648. 
• Corzo D, Gibson W, Johnson K, et al. (2002). "Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders.". Am. J. Hum. Genet. 70 (6): 1520–31. doi:10.1086/340849. PMC 419992. PMID 11992258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=419992. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria.". J. Biol. Chem. 278 (16): 14461–8. doi:10.1074/jbc.M209684200. PMID 12529377. 
• Mund T, Gewies A, Schoenfeld N, et al. (2003). "Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum.". FASEB J. 17 (6): 696–8. doi:10.1096/fj.02-0657fje. PMID 12594175.