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Breast cancer anti-estrogen resistance 1
Protein BCAR1 PDB 1wyx.png
PDB rendering based on 1wyx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCAR1 ; CAS; CAS1; CASS1; CRKAS; P130Cas
External IDs OMIM602941 MGI108091 HomoloGene7674 ChEMBL: 5559 GeneCards: BCAR1 Gene
RNA expression pattern
PBB GE BCAR1 gnf1h00170 at tn.png
More reference expression data
Species Human Mouse
Entrez 9564 12927
Ensembl ENSG00000050820 ENSMUSG00000031955
UniProt P56945 Q61140
RefSeq (mRNA) NM_001170714 NM_001198839
RefSeq (protein) NP_001164185 NP_001185768
Location (UCSC) Chr 16:
75.26 – 75.3 Mb
Chr 8:
111.71 – 111.74 Mb
PubMed search [1] [2]

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.[1][2]


  1. ^ Dorssers LC, van Agthoven T, Dekker A, van Agthoven TL, Kok EM (Oct 1993). "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site". Mol Endocrinol 7 (7): 870–8. doi:10.1210/me.7.7.870. PMID 8413311. 
  2. ^ Brinkman A, van der Flier S, Kok EM, Dorssers LC (Feb 2000). "BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells". J Natl Cancer Inst 92 (2): 112–20. doi:10.1093/jnci/92.2.112. PMID 10639512. 

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