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Breast cancer anti-estrogen resistance 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCAR3 ; NSP2; SH2D3B
External IDs OMIM604704 MGI1352501 HomoloGene31181 ChEMBL: 3177 GeneCards: BCAR3 Gene
RNA expression pattern
PBB GE BCAR3 204032 at tn.png
More reference expression data
Species Human Mouse
Entrez 8412 29815
Ensembl ENSG00000137936 ENSMUSG00000028121
UniProt O75815 Q9QZK2
RefSeq (mRNA) NM_001261408 NM_013867
RefSeq (protein) NP_001248337 NP_038895
Location (UCSC) Chr 1:
94.03 – 94.31 Mb
Chr 3:
122.42 – 122.53 Mb
PubMed search [1] [2]

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[1][2]


Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[2]


Further reading[edit]