BCAR3

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Breast cancer anti-estrogen resistance 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCAR3 ; NSP2; SH2D3B
External IDs OMIM604704 MGI1352501 HomoloGene31181 ChEMBL: 3177 GeneCards: BCAR3 Gene
RNA expression pattern
PBB GE BCAR3 204032 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8412 29815
Ensembl ENSG00000137936 ENSMUSG00000028121
UniProt O75815 Q9QZK2
RefSeq (mRNA) NM_001261408 NM_013867
RefSeq (protein) NP_001248337 NP_038895
Location (UCSC) Chr 1:
94.03 – 94.31 Mb
Chr 3:
122.42 – 122.53 Mb
PubMed search [1] [2]

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[1][2]

Function[edit]

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[2]

References[edit]

Further reading[edit]