BCL10

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B-cell CLL/lymphoma 10
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL10 ; CARMEN; CIPER; CLAP; c-E10; mE10
External IDs OMIM603517 MGI1337994 HomoloGene2912 GeneCards: BCL10 Gene
Orthologs
Species Human Mouse
Entrez 8915 12042
Ensembl ENSG00000142867 ENSMUSG00000028191
UniProt O95999 Q9Z0H7
RefSeq (mRNA) NM_003921 NM_009740
RefSeq (protein) NP_003912 NP_033870
Location (UCSC) Chr 1:
85.73 – 85.74 Mb
Chr 3:
145.92 – 145.93 Mb
PubMed search [1] [2]

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.[1][2] Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

Function[edit]

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.[2]

Interactions[edit]

BCL10 has been shown to interact with:


References[edit]

  1. ^ Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (March 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell 96 (1): 35–45. doi:10.1016/S0092-8674(00)80957-5. PMID 9989495. 
  2. ^ a b "Entrez Gene: BCL10 B-cell CLL/lymphoma 10". 
  3. ^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443. 
  4. ^ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. 
  5. ^ Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (Dec 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425. 
  6. ^ Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE (2012). "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes". J. Immunol. 188 (6): 2493–7. doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537. 
  7. ^ Wu CJ, Ashwell JD (February 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044. 
  8. ^ Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (October 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634. 
  9. ^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917. 

Further reading[edit]

  • Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389. 
  • Lee WC, Balsara B, Liu Z et al. (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma". Cancer Res. 56 (19): 4297–301. PMID 8813110. 
  • Koseki T, Inohara N, Chen S et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10". J. Biol. Chem. 274 (15): 9955–9961. doi:10.1074/jbc.274.15.9955. PMID 10187770. 
  • Thome M, Martinon F, Hofmann K et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase". J. Biol. Chem. 274 (15): 9962–9968. doi:10.1074/jbc.274.15.9962. PMID 10187771. 
  • Yan M, Lee J, Schilbach S et al. (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule". J. Biol. Chem. 274 (15): 10287–10292. doi:10.1074/jbc.274.15.10287. PMID 10187815. 
  • Zhang Q, Siebert R, Yan M et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)". Nat. Genet. 22 (1): 63–68. doi:10.1038/8767. PMID 10319863. 
  • Srinivasula SM, Ahmad M, Lin JH et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis". J. Biol. Chem. 274 (25): 17946–17954. doi:10.1074/jbc.274.25.17946. PMID 10364242. 
  • Apostolou S, De Rienzo A, Murthy SS et al. (1999). "Absence of BCL10 mutations in human malignant mesothelioma". Cell 97 (6): 684–686. doi:10.1016/S0092-8674(02)09765-9. PMID 10380921. 
  • Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–20132. doi:10.1074/jbc.274.29.20127. PMID 10400625. 
  • Yoneda T, Imaizumi K, Maeda M et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–11120. doi:10.1074/jbc.275.15.11114. PMID 10753917. 
  • Ye H, Dogan A, Karran L et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma". Am. J. Pathol. 157 (4): 1147–1154. doi:10.1016/S0002-9440(10)64630-5. PMC 1850175. PMID 11021819. 
  • Bertin J, Guo Y, Wang L et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–41086. doi:10.1074/jbc.C000726200. PMID 11053425. 
  • Uren AG, O'Rourke K, Aravind LA et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–967. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634. 
  • Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma". J. Biol. Chem. 276 (5): 3183–3187. doi:10.1074/jbc.C000792200. PMID 11113112. 
  • Ruland J, Duncan GS, Elia A et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure". Cell 104 (1): 33–42. doi:10.1016/S0092-8674(01)00189-1. PMID 11163238. 
  • Wang L, Guo Y, Huang WJ et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–21409. doi:10.1074/jbc.M102488200. PMID 11259443. 
  • Lucas PC, Yonezumi M, Inohara N et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway". J. Biol. Chem. 276 (22): 19012–19019. doi:10.1074/jbc.M009984200. PMID 11262391. 
  • Bertin J, Wang L, Guo Y et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–11882. doi:10.1074/jbc.M010512200. PMID 11278692. 
  • Gaide O, Martinon F, Micheau O et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–127. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.