BCL10

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B-cell CLL/lymphoma 10
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL10 ; CARMEN; CIPER; CLAP; c-E10; mE10
External IDs OMIM603517 MGI1337994 HomoloGene2912 GeneCards: BCL10 Gene
Orthologs
Species Human Mouse
Entrez 8915 12042
Ensembl ENSG00000142867 ENSMUSG00000028191
UniProt O95999 Q9Z0H7
RefSeq (mRNA) NM_003921 NM_009740
RefSeq (protein) NP_003912 NP_033870
Location (UCSC) Chr 1:
85.73 – 85.74 Mb
Chr 3:
145.92 – 145.93 Mb
PubMed search [1] [2]

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.[1][2] Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

Function[edit]

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.[2]

Interactions[edit]

BCL10 has been shown to interact with:


References[edit]

  1. ^ Willis T, Jadayel D, Du M, Peng H, Perry A, Abdul-Rauf M et al. (March 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell 96 (1): 35–45. doi:10.1016/S0092-8674(00)80957-5. PMID 9989495. 
  2. ^ a b "Entrez Gene: BCL10 B-cell CLL/lymphoma 10". 
  3. ^ Wang L, Guo Y, Huang W, Ke X, Poyet J, Manji G et al. (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443. 
  4. ^ Bertin J, Wang L, Guo Y, Jacobson M, Poyet J, Srinivasula S et al. (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. 
  5. ^ Bertin J, Guo Y, Wang L, Srinivasula S, Jacobson M, Poyet J et al. (Dec 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425. 
  6. ^ Lin Q, Liu Y, Moore D, Elizer S, Veach R, Hawiger J et al. (2012). "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes". J. Immunol. 188 (6): 2493–7. doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537. 
  7. ^ Wu C, Ashwell J (February 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044. 
  8. ^ Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E et al. (October 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634. 
  9. ^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T et al. (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917. 

Further reading[edit]

  • Bertoni F, Cavalli F, Cotter F, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389. 
  • Lee W, Balsara B, Liu Z, Jhanwar S, Testa J (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma". Cancer Res. 56 (19): 4297–301. PMID 8813110. 
  • Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger M et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10". J. Biol. Chem. 274 (15): 9955–9961. doi:10.1074/jbc.274.15.9955. PMID 10187770. 
  • Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase". J. Biol. Chem. 274 (15): 9962–9968. doi:10.1074/jbc.274.15.9962. PMID 10187771. 
  • Yan M, Lee J, Schilbach S, Goddard A, Dixit V (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule". J. Biol. Chem. 274 (15): 10287–10292. doi:10.1074/jbc.274.15.10287. PMID 10187815. 
  • Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)". Nat. Genet. 22 (1): 63–68. doi:10.1038/8767. PMID 10319863. 
  • Srinivasula S, Ahmad M, Lin J, Poyet J, Fernandes-Alnemri T, Tsichlis P et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis". J. Biol. Chem. 274 (25): 17946–17954. doi:10.1074/jbc.274.25.17946. PMID 10364242. 
  • Apostolou S, De Rienzo A, Murthy S, Jhanwar S, Testa J (1999). "Absence of BCL10 mutations in human malignant mesothelioma". Cell 97 (6): 684–686. doi:10.1016/S0092-8674(02)09765-9. PMID 10380921. 
  • Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–20132. doi:10.1074/jbc.274.29.20127. PMID 10400625. 
  • Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–11120. doi:10.1074/jbc.275.15.11114. PMID 10753917. 
  • Ye H, Dogan A, Karran L, Willis T, Chen L, Wlodarska I et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma". Am. J. Pathol. 157 (4): 1147–1154. doi:10.1016/S0002-9440(10)64630-5. PMC 1850175. PMID 11021819. 
  • Bertin J, Guo Y, Wang L, Srinivasula S, Jacobson M, Poyet J et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–41086. doi:10.1074/jbc.C000726200. PMID 11053425. 
  • Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–967. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634. 
  • Poyet J, Srinivasula S, Alnemri E (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma". J. Biol. Chem. 276 (5): 3183–3187. doi:10.1074/jbc.C000792200. PMID 11113112. 
  • Ruland J, Duncan G, Elia A, del Barco Barrantes I, Nguyen L, Plyte S et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure". Cell 104 (1): 33–42. doi:10.1016/S0092-8674(01)00189-1. PMID 11163238. 
  • Wang L, Guo Y, Huang W, Ke X, Poyet J, Manji G et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–21409. doi:10.1074/jbc.M102488200. PMID 11259443. 
  • Lucas P, Yonezumi M, Inohara N, McAllister-Lucas L, Abazeed M, Chen F et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway". J. Biol. Chem. 276 (22): 19012–19019. doi:10.1074/jbc.M009984200. PMID 11262391. 
  • Bertin J, Wang L, Guo Y, Jacobson M, Poyet J, Srinivasula S et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–11882. doi:10.1074/jbc.M010512200. PMID 11278692. 
  • Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–127. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.