This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Five alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported. 
In addition to the functions described above, BCL11A has been found to play a role in the suppression of fetal hemoglobin production. Therapeutic strategies aimed at increasing fetal globin production in diseases such as beta thalassemia and sickle cell anemia by inhibiting BCL11A are currently being explored.
^Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL et al. (November 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID11719382.CS1 maint: Date and year (link)
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Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res.8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID11347906.
Martín-Subero JI, Gesk S, Harder L, Sonoki T, Tucker PW, Schlegelberger B et al. (2002). "Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma". Blood99 (4): 1474–7. doi:10.1182/blood.V99.4.1474. PMID11830502.Vancouver style error (help)
Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG et al. (2002). "Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene". Leukemia16 (5): 937–9. doi:10.1038/sj.leu.2402480. PMID11986957.Vancouver style error (help)
Weniger MA, Pulford K, Gesk S, Ehrlich S, Banham AH, Lyne L et al. (2006). "Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma". Leukemia20 (10): 1880–2. doi:10.1038/sj.leu.2404324. PMID16871282.