BCL2-related protein A1

BCL2-related protein A1
Rendering based on PDB 2VM6.
Available structures PDB 2VM6, 3I1H, 3MQP
Identifiers
Symbols	BCL2A1; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1
External IDs	OMIM: 601056 MGI: 102687 HomoloGene: 2988 GeneCards: BCL2A1 Gene
Gene Ontology Molecular function • protein binding Cellular component • cytoplasm Biological process • anti-apoptosis • regulation of apoptosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	597	12044
Ensembl	ENSG00000140379	ENSMUSG00000074147
UniProt	Q16548	Q07440
RefSeq (mRNA)	NM_001114735.1	NM_009742.3
RefSeq (protein)	NP_001108207.1	NP_033872.1
Location (UCSC)	Chr 15: 80.25 – 80.26 Mb	Chr 9: 88.85 – 88.86 Mb
PubMed search	[1]	[2]

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.

This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

In melanocytic cells BCL2A1 gene expression may be regulated by MITF.

Interactions

BCL2-related protein A1 has been shown to interact with Bcl-2-associated death promoter and Bcl-2-associated X protein.

Further reading

• Choi SS, Park IC, Yun JW, et al. (1995). "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.". Oncogene 11 (9): 1693–8. PMID 7478596. 
• Lin EY, Orlofsky A, Berger MS, Prystowsky MB (1993). "Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.". J. Immunol. 151 (4): 1979–88. PMID 8345191. 
• Karsan A, Yee E, Kaushansky K, Harlan JM (1996). "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.". Blood 87 (8): 3089–96. PMID 8605321. 
• Karsan A, Yee E, Harlan JM (1996). "Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1.". J. Biol. Chem. 271 (44): 27201–4. doi:10.1074/jbc.271.44.27201. PMID 8910286. 
• Carrió R, López-Hoyos M, Jimeno J, et al. (1997). "A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death.". Am. J. Pathol. 149 (6): 2133–42. PMC 1865360. PMID 8952545. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1865360. 
• Kenny JJ, Knobloch TJ, Augustus M, et al. (1997). "GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes.". Oncogene 14 (8): 997–1001. doi:10.1038/sj.onc.1200898. PMID 9050999. 
• Choi SS, Park SH, Kim UJ, Shin HS (1997). "Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3.". Mamm. Genome 8 (10): 781–2. doi:10.1007/s003359900567. PMID 9321477. 
• Hsu SY, Kaipia A, McGee E, et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. doi:10.1073/pnas.94.23.12401. PMC 24966. PMID 9356461. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24966. 
• Takemoto Y, Furuta M, Sato M, et al. (1998). "Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.". J. Immunol. 161 (2): 625–30. PMID 9670936. 
• Zong WX, Edelstein LC, Chen C, et al. (1999). "The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis.". Genes Dev. 13 (4): 382–7. doi:10.1101/gad.13.4.382. PMC 316475. PMID 10049353. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316475. 
• Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members.". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646. 
• Lee HH, Dadgostar H, Cheng Q, et al. (1999). "NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9136–41. doi:10.1073/pnas.96.16.9136. PMC 17745. PMID 10430908. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17745. 
• Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999). "NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis.". Mol. Cell. Biol. 19 (9): 5923–9. PMC 84448. PMID 10454539. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84448. 
• Tomayko MM, Punt JA, Bolcavage JM, et al. (1999). "Expression of the Bcl-2 family member A1 is developmentally regulated in T cells.". Int. Immunol. 11 (11): 1753–61. doi:10.1093/intimm/11.11.1753. PMID 10545479. 
• Zhang H, Cowan-Jacob SW, Simonen M, et al. (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells.". J. Biol. Chem. 275 (15): 11092–9. doi:10.1074/jbc.275.15.11092. PMID 10753914. 
• Duriez PJ, Wong F, Dorovini-Zis K, et al. (2000). "A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor.". J. Biol. Chem. 275 (24): 18099–107. doi:10.1074/jbc.M908925199. PMID 10849436. 
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
• Bae J, Hsu SY, Leo CP, et al. (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.". Apoptosis 6 (5): 319–30. doi:10.1023/A:1011319901057. PMID 11483855. 
• Akari H, Bour S, Kao S, et al. (2001). "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors.". J. Exp. Med. 194 (9): 1299–311. doi:10.1084/jem.194.9.1299. PMC 2195969. PMID 11696595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195969.