BCL2-related protein A1

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BCL2-related protein A1
Protein BCL2A1 PDB 2VM6.png
Rendering based on PDB 2VM6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL2A1 ; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1
External IDs OMIM601056 MGI102687 HomoloGene2988 ChEMBL: 6044 GeneCards: BCL2A1 Gene
RNA expression pattern
PBB GE BCL2A1 205681 at tn.png
More reference expression data
Species Human Mouse
Entrez 597 12044
Ensembl ENSG00000140379 ENSMUSG00000093809
UniProt Q16548 Q07440
RefSeq (mRNA) NM_001114735 NM_009742
RefSeq (protein) NP_001108207 NP_033872
Location (UCSC) Chr 15:
80.25 – 80.26 Mb
Chr 9:
88.96 – 88.96 Mb
PubMed search [1] [2]

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.[1][2][3]


This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.[3]

In melanocytic cells BCL2A1 gene expression may be regulated by MITF.[4]


BCL2-related protein A1 has been shown to interact with:


  1. ^ Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G (March 1996). "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species". Hum Mol Genet 4 (11): 2025–32. doi:10.1093/hmg/4.11.2025. PMID 8589678. 
  2. ^ Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T (June 2003). "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens". J Exp Med 197 (11): 1489–500. doi:10.1084/jem.20021925. PMC 2193899. PMID 12771180. 
  3. ^ a b "Entrez Gene: BCL2A1 BCL2-related protein A1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ (Aug 15, 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7834–8. doi:10.1073/pnas.92.17.7834. PMC 41240. PMID 7644501. 
  6. ^ Zhang H, Cowan-Jacob SW, Simonen M, Greenhalf W, Heim J, Meyhack B (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells". J. Biol. Chem. 275 (15): 11092–9. doi:10.1074/jbc.275.15.11092. PMID 10753914. 
  7. ^ Bae J, Hsu SY, Leo CP, Zell K, Hsueh AJ (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis 6 (5): 319–30. doi:10.1023/A:1011319901057. PMID 11483855. 
  8. ^ Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 

Further reading[edit]