BCL2-related protein A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
BCL2-related protein A1
Protein BCL2A1 PDB 2VM6.png
Rendering based on PDB 2VM6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL2A1 ; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1
External IDs OMIM601056 MGI102687 HomoloGene2988 ChEMBL: 6044 GeneCards: BCL2A1 Gene
RNA expression pattern
PBB GE BCL2A1 205681 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 597 12044
Ensembl ENSG00000140379 ENSMUSG00000093809
UniProt Q16548 Q07440
RefSeq (mRNA) NM_001114735 NM_009742
RefSeq (protein) NP_001108207 NP_033872
Location (UCSC) Chr 15:
80.25 – 80.26 Mb
Chr 9:
88.96 – 88.96 Mb
PubMed search [1] [2]

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.[1][2][3]

Function[edit]

This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.[3]

In melanocytic cells BCL2A1 gene expression may be regulated by MITF.[4]

Interactions[edit]

BCL2-related protein A1 has been shown to interact with:

References[edit]

  1. ^ Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G (March 1996). "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species". Hum Mol Genet 4 (11): 2025–32. doi:10.1093/hmg/4.11.2025. PMID 8589678. 
  2. ^ Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T (June 2003). "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens". J Exp Med 197 (11): 1489–500. doi:10.1084/jem.20021925. PMC 2193899. PMID 12771180. 
  3. ^ a b "Entrez Gene: BCL2A1 BCL2-related protein A1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ (Aug 15, 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7834–8. doi:10.1073/pnas.92.17.7834. PMC 41240. PMID 7644501. 
  6. ^ Zhang H, Cowan-Jacob SW, Simonen M, Greenhalf W, Heim J, Meyhack B (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells". J. Biol. Chem. 275 (15): 11092–9. doi:10.1074/jbc.275.15.11092. PMID 10753914. 
  7. ^ Bae J, Hsu SY, Leo CP, Zell K, Hsueh AJ (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis 6 (5): 319–30. doi:10.1023/A:1011319901057. PMID 11483855. 
  8. ^ Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 

Further reading[edit]