BCL2L10

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BCL2-like 10 (apoptosis facilitator)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL2L10 ; BCL-B; Boo; Diva
External IDs OMIM606910 MGI1330841 HomoloGene8396 ChEMBL: 5988 GeneCards: BCL2L10 Gene
RNA expression pattern
PBB GE BCL2L10 221320 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10017 12049
Ensembl ENSG00000137875 ENSMUSG00000032191
UniProt Q9HD36 Q9Z0F3
RefSeq (mRNA) NM_020396 NM_013479
RefSeq (protein) NP_065129 NP_038507
Location (UCSC) Chr 15:
52.4 – 52.4 Mb
Chr 9:
75.35 – 75.35 Mb
PubMed search [1] [2]

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.[1][2][3]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.[3]

References[edit]

  1. ^ Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G (Jan 1999). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death". J Biol Chem 273 (49): 32479–86. doi:10.1074/jbc.273.49.32479. PMID 9829980. 
  2. ^ Song Q, Kuang Y, Dixit VM, Vincenz C (Feb 1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1". EMBO J 18 (1): 167–78. doi:10.1093/emboj/18.1.167. PMC 1171112. PMID 9878060. 
  3. ^ a b "Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator)". 

Further reading[edit]

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