The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.
^Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G (Jan 1999). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death". J Biol Chem273 (49): 32479–86. doi:10.1074/jbc.273.49.32479. PMID9829980.
Aouacheria A, Arnaud E, Venet S et al. (2001). "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis". Oncogene20 (41): 5846–55. doi:10.1038/sj.onc.1204740. PMID11593390.
Zhang H, Holzgreve W, De Geyter C (2002). "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway". Hum. Mol. Genet.10 (21): 2329–39. doi:10.1093/hmg/10.21.2329. PMID11689480.
Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma". Int. J. Clin. Oncol.8 (2): 83–9. doi:10.1007/s101470300015. PMID12720100.
Kang Y, Lee DC, Han J et al. (2007). "NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling". Biochem. Biophys. Res. Commun.359 (1): 76–82. doi:10.1016/j.bbrc.2007.05.090. PMID17532299.