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BCL2-like 13 (apoptosis facilitator)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL2L13 ; BCL-RAMBO; Bcl2-L-13; MIL1
External IDs MGI2136959 HomoloGene9111 GeneCards: BCL2L13 Gene
RNA expression pattern
PBB GE BCL2L13 217955 at tn.png
More reference expression data
Species Human Mouse
Entrez 23786 94044
Ensembl ENSG00000099968 ENSMUSG00000009112
UniProt Q9BXK5 P59017
RefSeq (mRNA) NM_001270726 NM_153516
RefSeq (protein) NP_001257655 NP_705736
Location (UCSC) Chr 22:
18.11 – 18.21 Mb
Chr 6:
120.84 – 120.89 Mb
PubMed search [1] [2]

BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the BCL2L13 gene.[1]


Bcl-rambo is a member of the Bcl-2 family of proteins that regulate apoptosis. In cells, Bcl-rambo is localized to the mitochondria, and its overexpression induces apoptosis that is blocked by caspase inhibitors, whereas inhibitors controlling upstream events of either the 'death receptor' (FLIP, FADD-DN) or the 'mitochondrial' pro-apoptotic pathway (Bcl-x(L)) had no effect. [2]


  1. ^ "Entrez Gene: BCL2L13 BCL2-like 13 (apoptosis facilitator)". 
  2. ^ Kataoka T, Holler N, Micheau O, Martinon F, Tinel A, Hofmann K, Tschopp J (June 2001). "Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension". J. Biol. Chem. 276 (22): 19548–54. doi:10.1074/jbc.M010520200. PMID 11262395. 

Further reading[edit]