BCL2L13

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BCL2-like 13 (apoptosis facilitator)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL2L13 ; BCL-RAMBO; Bcl2-L-13; MIL1
External IDs MGI2136959 HomoloGene9111 GeneCards: BCL2L13 Gene
RNA expression pattern
PBB GE BCL2L13 217955 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23786 94044
Ensembl ENSG00000099968 ENSMUSG00000009112
UniProt Q9BXK5 P59017
RefSeq (mRNA) NM_001270726 NM_153516
RefSeq (protein) NP_001257655 NP_705736
Location (UCSC) Chr 22:
18.11 – 18.21 Mb
Chr 6:
120.84 – 120.89 Mb
PubMed search [1] [2]

BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the BCL2L13 gene.[1]

Function[edit]

Bcl-rambo is a member of the Bcl-2 family of proteins that regulate apoptosis. In cells, Bcl-rambo is localized to the mitochondria, and its overexpression induces apoptosis that is blocked by caspase inhibitors, whereas inhibitors controlling upstream events of either the 'death receptor' (FLIP, FADD-DN) or the 'mitochondrial' pro-apoptotic pathway (Bcl-x(L)) had no effect. [2]

References[edit]

  1. ^ "Entrez Gene: BCL2L13 BCL2-like 13 (apoptosis facilitator)". 
  2. ^ Kataoka T, Holler N, Micheau O, Martinon F, Tinel A, Hofmann K, Tschopp J (June 2001). "Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension". J. Biol. Chem. 276 (22): 19548–54. doi:10.1074/jbc.M010520200. PMID 11262395. 

Further reading[edit]