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For BCl3, see Boron trichloride.
B-cell CLL/lymphoma 3
Protein BCL3 PDB 1k1a.png
PDB rendering based on 1k1a.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL3 ; BCL4; D19S37
External IDs OMIM109560 MGI88140 HomoloGene81738 GeneCards: BCL3 Gene
RNA expression pattern
PBB GE BCL3 204908 s at tn.png
PBB GE BCL3 204907 s at tn.png
More reference expression data
Species Human Mouse
Entrez 602 12051
Ensembl ENSG00000069399 ENSMUSG00000053175
UniProt P20749 Q9Z2F6
RefSeq (mRNA) NM_005178 NM_033601
RefSeq (protein) NP_005169 NP_291079
Location (UCSC) Chr 19:
45.25 – 45.26 Mb
Chr 7:
19.81 – 19.82 Mb
PubMed search [1] [2]

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.[1][2]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.[3]

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.


BCL3 has been shown to interact with:


  1. ^ Wulczyn FG, Naumann M, Scheidereit C (Sep 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature 358 (6387): 597–9. doi:10.1038/358597a0. PMID 1501714. 
  2. ^ Ohno H, Takimoto G, McKeithan TW (May 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell 60 (6): 991–7. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. 
  3. ^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3". 
  4. ^ a b c d Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352. 
  5. ^ a b c Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (Oct 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212. 
  6. ^ "Molecular Interaction Database". 
  7. ^ a b Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. 63 (23): 8293–301. PMID 14678988. 
  8. ^ Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213–22. PMC 413194. PMID 8428580. 
  9. ^ Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (Sep 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". EMBO J. 18 (17): 4766–78. doi:10.1093/emboj/18.17.4766. PMC 1171549. PMID 10469655. 
  10. ^ Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (Mar 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-b. PMID 8453667. 
  11. ^ Na SY, Choi HS, Kim JW, Na DS, Lee JW (Nov 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988. 

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