BCL3

For BCl₃, see Boron trichloride.

B-cell CLL/lymphoma 3
PDB rendering based on 1k1a.
Available structures PDB 1K1A, 1K1B
Identifiers
Symbols	BCL3; BCL4; D19S37
External IDs	OMIM: 109560 MGI: 88140 HomoloGene: 81738 GeneCards: BCL3 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • protein binding, bridging Cellular component • nucleus • nucleus • cytoplasm • Bcl3-Bcl10 complex • Bcl3/NF-kappaB2 complex • protein complex • perinuclear region of cytoplasm Biological process • protein import into nucleus, translocation • follicular dendritic cell differentiation • marginal zone B cell differentiation • humoral immune response mediated by circulating immunoglobulin • germinal center formation • transcription, DNA-dependent • response to DNA damage stimulus • I-kappaB kinase/NF-kappaB cascade • response to virus • response to UV-C • antimicrobial humoral response • extracellular matrix organization • DNA damage response, signal transduction by p53 class mediator • positive regulation of interferon-gamma production • T-helper 1 type immune response • regulation of NF-kappaB import into nucleus • negative regulation of tumor necrosis factor biosynthetic process • defense response to bacterium • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis • defense response to protozoan • regulation of apoptosis • negative regulation of apoptosis • T-helper 2 cell differentiation • positive regulation of interleukin-10 biosynthetic process • negative regulation of interleukin-8 biosynthetic process • positive regulation of translation • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • spleen development • regulation of DNA binding • maintenance of protein location in nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	602	12051
Ensembl	ENSG00000069399	ENSMUSG00000053175
UniProt	P20749	Q3U300
RefSeq (mRNA)	NM_005178.4	NM_033601.3
RefSeq (protein)	NP_005169.2	NP_291079.2
Location (UCSC)	Chr 19: 45.25 – 45.26 Mb	Chr 7: 20.39 – 20.41 Mb
PubMed search	[1]	[2]

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Interactions

BCL3 has been shown to interact with PIR, NFKB2, HTATIP, NFKB1, BARD1, EP300, COP9 constitutive photomorphogenic homolog subunit 5, C-jun, Retinoid X receptor alpha and C-Fos.

Further reading

• Franzoso G, Bours V, Park S et al (1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition". Nature 359 (6393): 339–42. doi:10.1038/359339a0. PMID 1406939. 
• Bhatia K, Huppi K, McKeithan T et al (1991). "Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes". Oncogene 6 (9): 1569–73. PMID 1923524. 
• Mills FC, Brooker JS, Camerini-Otero RD (1991). "Sequences of human immunoglobulin switch regions: implications for recombination and transcription". Nucleic Acids Res. 18 (24): 7305–16. doi:10.1093/nar/18.24.7305. PMC 332867. PMID 2124350. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=332867. 
• Crossen PE, Kennedy MA, Heaton DC, Morrison MJ (1993). "Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region". Genes Chromosomes Cancer 8 (1): 60–2. doi:10.1002/gcc.2870080110. PMID 7691160. 
• McKeithan TW, Ohno H, Dickstein J, Hume E (1995). "Genomic structure of the candidate proto-oncogene BCL3". Genomics 24 (1): 120–6. doi:10.1006/geno.1994.1588. PMID 7896265. 
• Zhang Q, Didonato JA, Karin M, McKeithan TW (1994). "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins". Mol. Cell. Biol. 14 (6): 3915–26. PMC 358758. PMID 8196632. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358758. 
• Fujita T, Nolan GP, Liou HC et al (1993). "The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers". Genes Dev. 7 (7B): 1354–63. doi:10.1101/gad.7.7b.1354. PMID 8330739. 
• Naumann M, Wulczyn FG, Scheidereit C (1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213–22. PMC 413194. PMID 8428580. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413194. 
• Bours V, Franzoso G, Azarenko V et al (1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-B. PMID 8453667. 
• Nolan GP, Fujita T, Bhatia K et al (1993). "The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner". Mol. Cell. Biol. 13 (6): 3557–66. PMC 359825. PMID 8497270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359825. 
• Watanabe N, Iwamura T, Shinoda T, Fujita T (1997). "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation". EMBO J. 16 (12): 3609–20. doi:10.1093/emboj/16.12.3609. PMC 1169985. PMID 9218802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169985. 
• Bundy DL, McKeithan TW (1998). "Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA". J. Biol. Chem. 272 (52): 33132–9. doi:10.1074/jbc.272.52.33132. PMID 9407099. 
• Weyrich AS, Dixon DA, Pabla R et al (1998). "Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5556–61. doi:10.1073/pnas.95.10.5556. PMC 20416. PMID 9576921. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20416. 
• Na SY, Choi HS, Kim JW et al (1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988. 
• Dechend R, Hirano F, Lehmann K et al (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352. 
• Na SY, Choi JE, Kim HJ et al (1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212. 
• Neumann M, Fries H, Scheicher C et al (2000). "Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells". Blood 95 (1): 277–85. PMID 10607713. 
• Brasier AR, Lu M, Hai T et al (2001). "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence". J. Biol. Chem. 276 (34): 32080–93. doi:10.1074/jbc.M102949200. PMID 11387332. 

External links

• FactorBook BCL3