BCL9

From Wikipedia, the free encyclopedia
Jump to: navigation, search
B-cell CLL/lymphoma 9
Protein BCL9 PDB 2gl7.png
PDB rendering based on 2gl7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BCL9 ; LGS
External IDs OMIM602597 MGI1924828 HomoloGene3191 GeneCards: BCL9 Gene
RNA expression pattern
PBB GE BCL9 204129 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 607 77578
Ensembl ENSG00000116128 ENSMUSG00000038256
UniProt O00512 Q9D219
RefSeq (mRNA) NM_004326 NM_029933
RefSeq (protein) NP_004317 NP_084209
Location (UCSC) Chr 1:
147.01 – 147.1 Mb
Chr 3:
97.2 – 97.23 Mb
PubMed search [1] [2]

B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.[1][2]

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.[2]

Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder. [3]

Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL10, it has clinical significance in lymphoma.

Related gene problems[edit]

References[edit]

  1. ^ Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ (Apr 1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21". Blood 91 (6): 1873–81. PMID 9490669. 
  2. ^ a b "Entrez Gene: BCL9 B-cell CLL/lymphoma 9". 
  3. ^ Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia; Junyan Li et al.; Arch Gen Psychiatry. 2011;68(3):232-240. doi:10.1001/archgenpsychiatry.2011.1

Further reading[edit]