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B-cell CLL/lymphoma 9
Protein BCL9 PDB 2gl7.png
PDB rendering based on 2gl7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL9 ; LGS
External IDs OMIM602597 MGI1924828 HomoloGene3191 GeneCards: BCL9 Gene
RNA expression pattern
PBB GE BCL9 204129 at tn.png
More reference expression data
Species Human Mouse
Entrez 607 77578
Ensembl ENSG00000116128 ENSMUSG00000038256
UniProt O00512 Q9D219
RefSeq (mRNA) NM_004326 NM_029933
RefSeq (protein) NP_004317 NP_084209
Location (UCSC) Chr 1:
147.01 – 147.1 Mb
Chr 3:
97.2 – 97.23 Mb
PubMed search [1] [2]

B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.[1][2]

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.[2]

Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder. [3]

Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL10, it has clinical significance in lymphoma.

Related gene problems[edit]


  1. ^ Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ (Apr 1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21". Blood 91 (6): 1873–81. PMID 9490669. 
  2. ^ a b "Entrez Gene: BCL9 B-cell CLL/lymphoma 9". 
  3. ^ Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia; Junyan Li et al.; Arch Gen Psychiatry. 2011;68(3):232-240. doi:10.1001/archgenpsychiatry.2011.1

Further reading[edit]