Forodesine

From Wikipedia, the free encyclopedia
  (Redirected from BCX-1777)
Jump to: navigation, search
Forodesine
Immucillin H.svg
Identifiers
CAS number 209799-67-7 YesY
PubChem 444499
ChemSpider 392417 N
KEGG D06596 YesY
ChEMBL CHEMBL218291 N
Jmol-3D images Image 1
Properties
Molecular formula C11H14N4O4
Molar mass 266.25 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Forodesine (INN; also known as Immucillin H) is a transition-state analog inhibitor of purine nucleoside phosphorylase[1] under development for the treatment of relapsed B-cell chronic lymphocytic leukemia

Immucillin H was originally discovered by Vern Schramm's laboratory at the Albert Einstein College of Medicine in New York and Industrial Research Limited in New Zealand.

Forodesine is being developed by BioCryst Pharmaceuticals as Fodosine. As of 2008, it is currently in phase II clinical trials.[2]

References[edit]