BIRC6

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Baculoviral IAP repeat containing 6
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BIRC6 ; APOLLON; BRUCE
External IDs OMIM605638 MGI1276108 HomoloGene7248 IUPHAR: 2796 GeneCards: BIRC6 Gene
Orthologs
Species Human Mouse
Entrez 57448 12211
Ensembl ENSG00000115760 ENSMUSG00000024073
UniProt Q9NR09 O88738
RefSeq (mRNA) NM_016252 NM_007566
RefSeq (protein) NP_057336 NP_031592
Location (UCSC) Chr 2:
32.58 – 32.84 Mb
Chr 17:
74.53 – 74.7 Mb
PubMed search [1] [2]

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[1][2]

Function[edit]

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[2]

Interactions[edit]

BIRC6 has been shown to interact with KIF23.[3]

Diseases[edit]

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers [4] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[5]).

References[edit]

  1. ^ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019. 
  2. ^ a b "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)". 
  3. ^ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369. 
  4. ^ http://atlasgeneticsoncology.org/Genes/BIRC6ID798ch2p22.html
  5. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org. 

Further reading[edit]