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BCL2/adenovirus E1B 19kDa interacting protein 3
Protein BNIP3 PDB 2j5d.png
PDB rendering based on 2j5d.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BNIP3 ; NIP3
External IDs OMIM603293 MGI109326 HomoloGene2990 GeneCards: BNIP3 Gene
RNA expression pattern
PBB GE BNIP3 201849 at tn.png
PBB GE BNIP3 201848 s at tn.png
More reference expression data
Species Human Mouse
Entrez 664 12176
Ensembl ENSG00000176171 ENSMUSG00000078566
UniProt Q12983 O55003
RefSeq (mRNA) NM_004052 NM_009760
RefSeq (protein) NP_004043 NP_033890
Location (UCSC) Chr 10:
133.78 – 133.8 Mb
Chr 7:
138.89 – 138.91 Mb
PubMed search [1] [2]

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the BNIP3 gene.[1]

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.[2]


BNIP3 has been shown to interact with CD47,[3] BCL2-like 1[4] and Bcl-2.[1][4]


  1. ^ a b Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. 
  2. ^ "Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3". 
  3. ^ Lamy, Laurence; Ticchioni Michel, Rouquette-Jazdanian Alexandre K, Samson Michel, Deckert Marcel, Greenberg Arnold H, Bernard Alain (June 2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis". J. Biol. Chem. (United States) 278 (26): 23915–21. doi:10.1074/jbc.M301869200. ISSN 0021-9258. PMID 12690108. 
  4. ^ a b Ray, R; Chen G; Vande Velde C; Cizeau J; Park J H; Reed J C; Gietz R D; Greenberg A H (January 2000). "BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites". J. Biol. Chem. (UNITED STATES) 275 (2): 1439–48. doi:10.1074/jbc.275.2.1439. ISSN 0021-9258. PMID 10625696. 

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