BOP1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Block of proliferation 1
Identifiers
Symbols BOP1 ; KIAA0124
External IDs OMIM610596 MGI1334460 HomoloGene6612 GeneCards: BOP1 Gene
RNA expression pattern
PBB GE BOP1 212563 at tn.png
PBB GE BOP1 216397 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23246 12181
Ensembl ENSG00000170727 ENSMUSG00000022557
UniProt Q14137 P97452
RefSeq (mRNA) NM_015201 NM_013481
RefSeq (protein) NP_056016 NP_038509
Location (UCSC) Chr 8:
145.49 – 145.52 Mb
Chr 15:
76.45 – 76.48 Mb
PubMed search [1] [2]

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.[1][2]

Function[edit]

It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.[3] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.[4] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.[5]

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.[6] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1.[3]

Structure[edit]

BOP1NT
Identifiers
Symbol BOP1NT
Pfam PF08145
InterPro IPR012953

BOP1 contains a conserved N-terminal domain, BOP1NT.

References[edit]

  1. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280. 
  2. ^ "Entrez Gene: BOP1 block of proliferation 1". 
  3. ^ a b Kim J, Goo SY, Chung HJ, Yang HW, Yong TS, Lee KH, Park SJ (January 2006). "Interaction of beta-giardin with the Bop1 protein in Giardia lamblia". Parasitol. Res. 98 (2): 138–44. doi:10.1007/s00436-005-0040-8. PMID 16362343. 
  4. ^ Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F, Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T (September 2006). "Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis". Genes Chromosomes Cancer 45 (9): 874–81. doi:10.1002/gcc.20351. PMID 16804918. 
  5. ^ Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit". Mol. Cell. Biol. 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269. 
  6. ^ Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D (August 2005). "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation". J. Cell Biol. 170 (3): 367–78. doi:10.1083/jcb.200501141. PMC 2171466. PMID 16043514. 

Further reading[edit]

This article incorporates text from the public domain Pfam and InterPro IPR012953