BQ-123

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BQ-123[1]
BQ-123 structure.svg
Names
IUPAC name
2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
Other names
Cyclo(D-trp-D-asp-L-pro-D-val-L-leu)
Identifiers
136553-81-6 YesY
ChEMBL ChEMBL1269102 N
ChemSpider 25069753 N
IUPHAR ligand 997
Jmol-3D images Image
PubChem 443289
Properties
C31H42N6O7
Molar mass 610.70 g·mol−1
Hazards
S-phrases S22 S24/25
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

BQ-123 is a cyclic peptide consisting of five amino acids. The amino acid sequence is D-tryptamine-D-aspartic acid-L-proline-D-valine-L-leucine.

BQ-123 is a selective ETA endothelin receptor antagonist.[1][2] As such, it is used as a biochemical tool in the study of endothelin receptor function.


References[edit]

  1. ^ a b BQ-123 at Sigma-Aldrich
  2. ^ Ishikawa, Kiyofumi; Fukami, Takehiro; Nagase, Toshio; Fujita, Kagari; Hayama, Takashi; Niiyama, Kenji; Mase, Toshiaki; Ihara, Masaki; Yano, Mitsuo (1992). "Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.". Journal of Medicinal Chemistry 35 (11): 1239–42. doi:10.1021/jm00089a028.