BQ-123

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BQ-123[1]
BQ-123 structure.svg
Identifiers
CAS number 136553-81-6 YesY
PubChem 443289
ChemSpider 25069753 N
ChEMBL CHEMBL1269102 N
IUPHAR ligand 997
Jmol-3D images Image 1
Properties
Molecular formula C31H42N6O7
Molar mass 610.70 g mol−1
Hazards
S-phrases S22 S24/25
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

BQ-123 is a cyclic peptide consisting of five amino acids. The amino acid sequence is D-tryptamine-D-aspartic acid-L-proline-D-valine-L-leucine.

BQ-123 is a selective ETA endothelin receptor antagonist.[1][2] As such, it is used as a biochemical tool in the study of endothelin receptor function.


References[edit]

  1. ^ a b BQ-123 at Sigma-Aldrich
  2. ^ Ishikawa, Kiyofumi; Fukami, Takehiro; Nagase, Toshio; Fujita, Kagari; Hayama, Takashi; Niiyama, Kenji; Mase, Toshiaki; Ihara, Masaki; Yano, Mitsuo (1992). "Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.". Journal of Medicinal Chemistry 35 (11): 1239–42.