This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.
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^ abcdefgDong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK et al. (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID14636569.
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