BRCC3

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BRCA1/BRCA2-containing complex, subunit 3
Identifiers
Symbols BRCC3 ; BRCC36; C6.1A; CXorf53
External IDs OMIM300617 MGI2389572 HomoloGene11530 GeneCards: BRCC3 Gene
EC number 3.1.2.15
RNA expression pattern
PBB GE BRCC3 216521 s at tn.png
PBB GE BRCC3 221196 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79184 210766
Ensembl ENSG00000185515 ENSMUSG00000031201
UniProt P46736 P46737
RefSeq (mRNA) NM_001018055 NM_001166457
RefSeq (protein) NP_001018065 NP_001159929
Location (UCSC) Chr HG1497_PATCH:
154.24 – 154.29 Mb
Chr X:
75.42 – 75.45 Mb
PubMed search [1] [2]

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.[1][2][3]

Function[edit]

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.[3]

Interactions[edit]

BRCC3 has been shown to interact with BRE,[2][4] BRCA2,[2] RAD51,[2] BRCA1,[2] P53[2] and BARD1.[2]

References[edit]

  1. ^ Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (Jun 1992). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175. 
  2. ^ a b c d e f g Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK et al. (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569. 
  3. ^ a b "Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3". 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]